Evidence map›Paper›PMID 29371112›Full record

SynthesisThe spine journal : official journal of the North American Spine Society2018

Manipulation and mobilization for treating chronic low back pain: a systematic review and meta-analysis.

Ian D Coulter, Cindy Crawford, Eric L Hurwitz, Howard Vernon, Raheleh Khorsan, Marika Suttorp Booth, Patricia M Herman

4 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The spine journal : official journal of the North American Spine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 87 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 7 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04387032 nacompletednot on this mapstarted 2019, after this paper: background citation

The Influence of the Sacroiliac Joint Manipulation on Changes in the Values of the Center of Pressure in the Process of Maintaining Static Body Balance

TypeinterventionalSponsorPoznan University of Physical EducationRan2019 to 2019Enrolled59ConditionsAsymptomatic Condition, Sacroiliac DisorderArmsHVLA Manipulations, Sham Manipulation
NCT04521244 nacompletednot on this mapstarted 2019, after this paper: background citation

Immediate Effects of Thrust Versus Non-thrust Lumbar Manipulation on Mobility and Springing Force Tolerance in Lumbar Hypomobility

TypeinterventionalSponsorRiphah International UniversityRan2019 to 2020Enrolled30ConditionsHypomotility, Lumbar Spine InstabilityArmsThrust joint lumbar manipulation, Lumbar mobilization
NCT05214456 naunknown statusnot on this mapstarted 2022, after this paper: background citation

To Compare the Effect of Dry Needling Versus Lumbar Spine Mobilization on Symptoms in Patients With Chronic Nonspecific Low Back Pain

TypeinterventionalSponsorIran University of Medical SciencesRan2022 to 2023Enrolled56ConditionsLow Back PainArmsDry needling, Mobilization
NCT05905562 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Core Muscle Activation Exercise Training Program on Pain, Range of Motion, and Function in Patients With Chronic Low Back Pain

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled34ConditionsLow Back PainArmscore stabilization exercises, Spinal mobilization techniques
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 7 syntheses or guidelines pooled it, 240 citations in OpenAlex.

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  10. The Effect of Massage Force on Relieving Nonspecific Low Back Pain: A Randomized Controlled Trial.International journal of environmental research and public health · 2022
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ian D CoulterRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA; UCLA School of Dentistry, Box 951668, Los Angeles, CA 90095-1668, USA; Southern California University of Health Sciences, 16200 Amber Valley Dr, Whittier, CA 90604, USA. Electronic address: coulter@rand.org.
Cindy CrawfordRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA.
Eric L HurwitzRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA; Office of Public Health Studies, University of Hawai'i, Mānoa, 1960 East-West Rd, Biomed D104AA, Honolulu, HI 96822, USA.
Howard VernonRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA; Division of Research, Canadian Memorial Chiropractic College, 6100 Leslie St, Toronto, ON, Canada M2H 3J1.
Raheleh KhorsanUCI Department of Urban Planning and Public Policy, 300 Social Ecology I, Irvine, CA 92697-7075, USA.
Marika Suttorp BoothRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA.
Patricia M HermanRAND Corporation, 1776 Main St, Santa Monica, CA 90407-2138, USA.
RAND Corporation · USUniversity of Hawaiʻi at Mānoa · US

Funding

Systematic Review Core (SRC)/Ian D. CoulterU19AT007912 · NCCIH · RAND CORPORATION · PI COULTER, IAN DOUGLASS, HERMAN, PATRICIA M · 2013 to 2017
$8.5M
NCCIH NIH HHS U19 AT007912
6 · The paper itself

Abstract

background contextMobilization and manipulation therapies are widely used to benefit patients with chronic low back pain. However, questions remain about their efficacy, dosing, safety, and how these approaches compare with other therapies. PURPOSE: The present study aims to determine the efficacy, effectiveness, and safety of various mobilization and manipulation therapies for treatment of chronic low back pain. STUDY DESIGN/

settingThis is a systematic literature review and meta-analysis. OUTCOME MEASURES: The present study measures self-reported pain, function, health-related quality of life, and adverse events.

methodsWe identified studies by searching multiple electronic databases from January 2000 to March 2017, examining reference lists, and communicating with experts. We selected randomized controlled trials comparing manipulation or mobilization therapies with sham, no treatment, other active therapies, and multimodal therapeutic approaches. We assessed risk of bias using Scottish Intercollegiate Guidelines Network criteria. Where possible, we pooled data using random-effects meta-analysis. Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was applied to determine the confidence in effect estimates. This project is funded by the National Center for Complementary and Integrative Health under Award Number U19AT007912.

resultsFifty-one trials were included in the systematic review. Nine trials (1,176 patients) provided sufficient data and were judged similar enough to be pooled for meta-analysis. The standardized mean difference for a reduction of pain was SMD=-0.28, 95% confidence interval (CI) -0.47 to -0.09, p=.004; I

conclusionThere is moderate-quality evidence that manipulation and mobilization are likely to reduce pain and improve function for patients with chronic low back pain; manipulation appears to produce a larger effect than mobilization. Both therapies appear safe. Multimodal programs may be a promising option.

Indexed as

Chronic PainClinical Trials as TopicHumansLow Back PainManipulation, ChiropracticChiropracticChronic low back painManipulationMeta-analysisMobilizationSystematic review

Identifiers

PMID29371112
PMCPMC6020029
OpenAlexW2791581100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.