ArticleParasites & vectors2018
Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited.International journal for parasitology. Drugs and drug resistance · 2023Pooled it
- Progress in serology and molecular biology of equine parasite diagnosis: sustainable control strategies.Frontiers in veterinary science · 2025Review
- Patterns of Equine Small Strongyle Species Infection after Ivermectin Intervention in Thailand: Egg Reappearance Period and Nemabiome Metabarcoding Approach.Animals : an open access journal from MDPI · 2024Article
- Prevalence, Associated Risk Factors, and Identification of the Genera of Equine Strongyles in Horses and Donkeys in and Around Bishoftu, Ethiopia.Veterinary medicine international · 2024Article
- Anthelmintic resistance in equine nematodes: Current status and emerging trends.International journal for parasitology. Drugs and drug resistance · 2022Review
- Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.Parasites & vectors · 2021Article
- Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm.International journal for parasitology. Drugs and drug resistance · 2020Article
- A Controlled Study on Efficacy and Egg Reappearance Period of Ivermectin in Donkeys Naturally Infected with Small Strongyles.Helminthologia · 2020Article
- Horses grazing with cattle have reduced strongyle egg count due to the dilution effect and increased reliance on macrocyclic lactones in mixed farms.Animal : an international journal of animal bioscience · 2020Article
- Prevalence ofVeterinary parasitology: X · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn spite of the emergence of populations of drug-resistant cyathostomines worldwide, little is known of parasite species responsible for 'early egg shedding' in cohorts of horses subjected to treatment with widely used anthelmintics, e.g. ivermectin (IVM). In this study, we determined the cyathostomine egg reappearance period (ERP) after IVM treatment in a cohort of yearlings from a large Thoroughbred (TB) stud farm in the United Kingdom, and identified species of cyathostomines with reduced ERP using a combination of fundamental parasitology techniques coupled with advanced molecular tools.
methodsIndividual faecal samples were collected from TB yearlings with cyathostomine infection prior to IVM treatment, as well as at 14, 21, 28, 35, 42 and 49 days post-treatment. Faecal egg counts (FEC) were performed for each individual sample for determination of ERPs. In addition, individual larval cultures were performed and representative numbers of third-stage larvae (L3s) harvested from each culture were subjected to molecular species identification via PCR-Reverse Line Blot (RLB).
resultsPrior to IVM treatment, 11 cyathostomine species were detected in faecal samples from TB horses enrolled in this study, i.e. Cyathostomum catinatum, Cylicostephanus longibursatus, Cylicostephanus goldi, Cylicocyclus nassatus, Cylicostephanus calicatus, Cyathostomum pateratum, Cylicocyclus radiatus, Paraposteriostomum mettami, Coronocyclus labratus, Cylicocyclus insigne and Cylicocyclus radiatus variant A. Of these, eggs of Cya. catinatum, Cys. longibursatus, Cyc. nassatus and Cyc. radiatus could be detected at 28 days post-treatment, while from day 42 onwards, cyathostomine species composition reflected data obtained pre-IVM treatment, with the exception of eggs of Cor. labratus and Cyc. insigne which could no longer be detected post-IVM administration.
conclusionsThis study provides valuable data on the occurrence of IVM-resistance in cyathostomines in the UK. Nevertheless, further investigations are needed to shed light on the prevalence and incidence of drug-resistance in this country, as well as other areas of the world where equine trade is substantial.
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