ReviewParasites & vectors2018
Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research.
Review in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Occupational risk of cutaneous larva migrans: A case report and a systematic literature review.PLoS neglected tropical diseases · 2022Pooled it
- Participation in a Short-Term Socialization and Training Program Improved Kennel-Raised Dog Welfare.Animals : an open access journal from MDPI · 2026Article
- High prevalence of gastrointestinal parasites in dogs from Saipan, Northern Mariana Islands, including the zoonotic Ancylostoma ceylanicum.Parasites & vectors · 2026Article
- Public Spaces as Hotspots of Zoonotic Gastrointestinal Parasite Transmission: Evidence from Small Animal and Soil Surveillance in Malaysia.Journal of epidemiology and global health · 2026Article
- Beyond Motility: A Multiparametric Fitness Assay Framework to Evaluate Anthelmintics inbioRxiv : the preprint server for biology · 2025Article
- Anthroponotic and Zoonotic Hookworm DNA in an Indigenous Community in Coastal Ecuador: Potential Cross-Transmission between Dogs and Humans.Pathogens (Basel, Switzerland) · 2024Article
- Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review.PLoS neglected tropical diseases · 2024Article
- An efficient method for viable cryopreservation and recovery of hookworms and other gastrointestinal nematodes in the laboratory.International journal for parasitology · 2023Article
- Gastrointestinal helminth parasites of pets: Retrospective study at the veterinary teaching hospital, IPB University, Bogor, Indonesia.Veterinary world · 2023Article
- Article
- A Pilot Comparison of Fixatives for Hookworm Real-time Polymerase Chain Reaction.The American journal of tropical medicine and hygiene · 2023Article
- Comparison of coproprevalence and seroprevalence to guide decision-making in national soil-transmitted helminthiasis control programs: Ethiopia as a case study.PLoS neglected tropical diseases · 2022Article
- Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Organoids as tools to investigate gastrointestinal nematode development and host interactions.Frontiers in cellular and infection microbiology · 2022Article
- Identification of antigenic linear peptides in the soil-transmitted helminth and Schistosoma mansoni proteome.PLoS neglected tropical diseases · 2021Article
- An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae.ZooKeys · 2021Article
- Development of a New LAMP Assay for the Detection ofFrontiers in veterinary science · 2021Article
- Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.Frontiers in cellular and infection microbiology · 2021Review
- The Control of Zoonotic Soil-Transmitted Helminthoses Using Saprophytic Fungi.Pathogens (Basel, Switzerland) · 2020Article
- High prevalence of Ancylostoma caninum infection in black-eared opossums (Didelphis aurita) in an urban environment.Parasitology research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We present evidence that the dog hookworm (Ancylostoma caninum) is underutilised in the study of host-parasite interactions, particularly as a proxy for the human-hookworm relationship. The inability to passage hookworms through all life stages in vitro means that adult stage hookworms have to be harvested from the gut of their definitive hosts for ex vivo research. This makes study of the human-hookworm interface difficult for technical and ethical reasons. The historical association of humans, dogs and hookworms presents a unique triad of positive evolutionary pressure to drive the A. caninum-canine interaction to reflect that of the human-hookworm relationship. Here we discuss A. caninum as a proxy for human hookworm infection and situate this hookworm model within the current research agenda, including the various 'omics' applications and the search for next generation biologics to treat a plethora of human diseases. Historically, the dog hookworm has been well described on a physiological and biochemical level, with an increasing understanding of its role as a human zoonosis. With its similarity to human hookworm, the recent publications of hookworm genomes and other omics databases, as well as the ready availability of these parasites for ex vivo culture, the dog hookworm presents itself as a valuable tool for discovery and translational research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.