Evidence map›Paper›PMID 29370825›Full record

ArticleAlzheimer's research & therapy2018

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries.

Levinia Lim, Tze Pin Ng, Anam Paulus Ong, Maw Pin Tan, Alvin Rae Cenina, Qi Gao, Adeline Ng, Nagaendran Kandiah

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Levinia LimDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Tze Pin NgGerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine National University of Singapore, Singapore, Singapore.
Anam Paulus OngFaculty of Medicine, Department of Neurology, Hasan Sadikin Hospital, Padjadjaran University, Kota Bandung, Jawa Barat, Indonesia.
Maw Pin TanDepartment of Medicine, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia.
Alvin Rae CeninaDepartment of Neurosciences, Philippine General Hospital, University of the Philippines, Manila, Philippines.
Qi GaoGerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine National University of Singapore, Singapore, Singapore.
Adeline NgDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Nagaendran KandiahDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore. nagaendran.kandiah@singhealth.com.sg.ORCID 0000-0001-9244-4298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive screeners are imperative for early diagnosis of dementia. The Visual Cognitive Assessment Test (VCAT) is a language-neutral, visual-based test which has proven useful for a multilingual population in a single-center study. However, its performance utility is unknown in a wider and more diverse Southeast Asian cohort.

methodsWe recruited 164 healthy controls (HC) and 120 cognitively impaired (CI) subjects- 47 mild cognitive impairment (MCI) and 73 mild Alzheimer's disease (AD) dementia participants, from four countries between January 2015 and August 2016 to determine the usefulness of a single version of the VCAT, without translation or adaptation, in a multinational, multilingual population. The VCAT was administered along with established cognitive evaluation.

resultsThe VCAT, without local translation or adaptation, was effective in discriminating between HC and CI subjects (MCI and mild AD dementia). Mean (SD) VCAT scores for HC and CI subjects were 22.48 (3.50) and 14.17 (5.05) respectively. Areas under the curve for Montreal Cognitive Assessment (0.916, 95% CI 0.884-0.948) and the VCAT (0.905, 95% CI 0.870-0.940) in discriminating between HCs and CIs were comparable. The multiple languages used to administer VCAT in four countries did not significantly influence test scores.

conclusionsThe VCAT without the need for language translation or cultural adaptation showed satisfactory discriminative ability and was effective in a multinational, multilingual Southeast Asian population.

Indexed as

Neuropsychological TestsAgedAlzheimer DiseaseAsia, SoutheasternCognitive DysfunctionCultureFemaleHumansLanguageMalePhotic StimulationProspective StudiesROC CurveAlzheimer’s diseaseCognitive testDementiaMild cognitive impairmentScreening tool

Identifiers

PMID29370825
PMCPMC6389153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.