Evidence map›Paper›PMID 29370756›Full record

Trial reportBMC geriatrics2018

Centre- versus home-based exercise among people with mci and mild dementia: study protocol for a randomized parallel-group trial.

Laura E Middleton, Sandra E Black, Nathan Herrmann, Paul I Oh, Kayla Regan, Krista L Lanctot

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02774720 (How do we Get People With MCI and Dementia to be Physically Active?), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02774720 nacompletednot on this map

How do we Get People With MCI and Dementia to be Physically Active?

TypeinterventionalSponsorUniversity of WaterlooRan2016 to 2019Enrolled44ConditionsMild Cognitive Impairment, DementiaArmsCentre-based exercise, Home-based exercise
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Laura E MiddletonUniversity of Waterloo, 200 University Ave W (BMH 1114), Waterloo, ON, N2L 3G1, Canada. laura.middleton@uwaterloo.ca.
Sandra E BlackSunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.
Nathan HerrmannSunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.
Paul I OhUniversity Health Network, 347 Rumsey Rd, Toronto, ON, M4G 2V6, Canada.
Kayla ReganUniversity of Waterloo, 200 University Ave W (BMH 1114), Waterloo, ON, N2L 3G1, Canada.
Krista L LanctotSunnybrook Research Institute, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.
Sunnybrook Health Science Centre · CAUniversity of Waterloo · CASunnybrook Research InstituteUniversity Health Network · CA

Funding

Alzheimer's Association 2016-NIRG-396241
6 · The paper itself

Abstract

backgroundWorldwide, almost 50million people lived with dementia in 2016. A cure or disease modifying pharmaceutical treatment for dementia remains elusive so alternative therapies are of critical importance. Mounting evidence supports exercise in the prevention and therapy of dementia. However, the cognitive, physical, and psychological challenges common to dementia along with a poor understanding and accommodation of dementia in the community are major barriers to exercise. Consequently, effective delivery options need to be identified. The primary objective of this study is to compare the effectiveness of center-based (CB) exercise versus home-based (HB) exercise for achievement of physical activity guidelines among people with MCI or mild dementia.

methodsThis is a randomized parallel-group trial comparing the effects of CB and HB exercise adherence among community-dwelling adults ≥50 years with a clinical diagnosis of MCI or mild dementia. Participants will be randomized to either CB or HB exercise. The CB group will meet weekly for small group exercise and will be prescribed additional exercise to be completed independently. Participants in the HB group will be given a physical activity prescription to be completed independently in the community. Participants in HB will also be contacted by phone monthly to adjust exercise prescriptions. The primary outcome will be achievement of exercise guidelines (150 min/wk. of moderate activity) assessed using an activity monitor. Secondary objectives will evaluate cost-effectiveness and the influence of individual and environmental factors on the primary outcome. Tertiary outcomes include physical function, cognition, mood, and quality of life. DISCUSSION: There is scant research to indicate the most effective way to deliver exercise to people with MCI and mild dementia, which is needed specifically because these groups face significant barriers to exercise. To capitalize on the benefits of exercise, feasible exercise delivery options need to be identified. The results of this study will directly complement ongoing clinical trials and will be essential to implementing exercise recommendations specific to the prevention and therapy of dementia in a feasible and cost-effective manner when they emerge.

trial registrationClinicatrials.gov ; Identifier: NCT02774720 (version updated December 12, 2016).

Indexed as

ExerciseHome Care ServicesRehabilitation CentersAdultAgedCognitive DysfunctionDementiaExercise TherapyFemaleHumansMaleQuality of LifeClinical trialDelivery of health careDementiaExerciseMild cognitive impairment

Identifiers

PMID29370756
PMCPMC5785893
OpenAlexW2794586056

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.