ArticleBMC genomics2018
Genome-wide association analysis and QTL mapping reveal the genetic control of cadmium accumulation in maize leaf.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Advancing crop improvement through GWAS and beyond in mung bean.Frontiers in plant science · 2024Pooled it
- Genetic basis of cadmium accumulation and tolerance in maize seedlings uncovered through integrated linkage mapping and transcriptome analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Integrating transcriptome and metabolome to reveal the characteristics of gene expression profiles and metabolite changes ofFrontiers in plant science · 2025Article
- Integrating QTL mapping and GWAS to decipher the genetic mechanisms behind the calcium contents ofFrontiers in plant science · 2025Article
- Abiotic stress responses in forage crops and grasses: the role of secondary metabolites and biotechnological interventions.Frontiers in plant science · 2025Review
- Defense guard: strategies of plants in the fight against Cadmium stress.Advanced biotechnology · 2024Review
- Multiomics and biotechnologies for understanding and influencing cadmium accumulation and stress response in plants.Plant biotechnology journal · 2024Review
- 6-Methyl-5-hepten-2-one promotes programmed cell death during superficial scald development in pear.Molecular horticulture · 2024Article
- A combination of QTL mapping and genome-wide association study revealed the key gene for husk number in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- New Insights into the Bio-Chemical Changes in Wheat Induced by Cd and Drought: What Can We Learn on Cd Stress Using Neutron Imaging?Plants (Basel, Switzerland) · 2024Article
- The maize WRKY transcription factor ZmWRKY64 confers cadmium tolerance in Arabidopsis and maize (Zea mays L.).Plant cell reports · 2024Article
- Genome-wide association analysis of four yield-related traits using a maize (Zea mays L.) F1 population.PloS one · 2024Article
- Phenotypic and Proteomic Insights into Differential Cadmium Accumulation in Maize Kernels.Genes · 2023Article
- Genetic dissection of maize (Zea maysL.) trace element traits using genome-wide association studies.BMC plant biology · 2023Article
- Comprehensive meta-analysis of QTL and gene expression studies identify candidate genes associated withFrontiers in plant science · 2023Article
- QTL and Candidate Genes: Techniques and Advancement in Abiotic Stress Resistance Breeding of Major Cereals.International journal of molecular sciences · 2022Review
- OMICS in Fodder Crops: Applications, Challenges, and Prospects.Current issues in molecular biology · 2022Review
- GWAS and bulked segregant analysis reveal the Loci controlling growth habit-related traits in cultivated Peanut (Arachis hypogaea L.).BMC genomics · 2022Article
- Genetic Architecture of Heterophylly: Single and Multi-Leaf Genome-Wide Association Mapping inFrontiers in plant science · 2022Article
- Biparental Crossing and QTL Mapping for Validation of Genome-Wide Association Studies.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAccumulation of cadmium (Cd) in maize (Zea mays L.) poses a significant risk to human health as it is ingested via the food chain. A genome-wide association study (GWAS) was conducted in a population of 269 maize accessions with 43,737 single nucleotide polymorphisms (SNPs) to identify candidate genes and favorable alleles for controlling Cd accumulation in maize.
resultsWhen grown in contaminated soil, accessions varied significantly in leaf Cd concentration at both the seeding and maturing stages with phenotypic variation and the coefficient of variation all above 48%. The co-localized region between SYN27837 (147,034,650 bp) and SYN36598 (168,551,327 bp) on chromosome 2 was associated with leaf Cd under three soil conditions varying in Cd content in 2015 and 2016. The significant SNP (SYN25051) at position 161,275,547 could explained 27.1% of the phenotype variation. Through QTL mapping using the IBMSyn10 double haploid (DH) population, we validated the existence of a major QTL identified by GWAS; qLCd2 could explain the 39.8% average phenotype variation across the experiments. Expression of GRMZM2G175576 encoding a cadmium/zinc-transporting ATPase underlying the QTL was significantly increased in roots, stems and leaves of B73, a low Cd accumulation line in response to Cd stress.
conclusionsOur findings provide new insights into the genetic control of Cd accumulation and could aid rapid development of maize genotypes with low-Cd accumulation by manipulation of the favorable alleles.
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