ArticleSchizophrenia bulletin2019
Negative Symptoms in Early-Onset Psychosis and Their Association With Antipsychotic Treatment Failure.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Natural language processing with machine learning methods to analyze unstructured patient-reported outcomes derived from electronic health records: A systematic review.Artificial intelligence in medicine · 2023Pooled it
- Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses.Molecular psychiatry · 2023Pooled it
- Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2023Pooled it
- The Potential of Research Drawing on Clinical Free Text to Bring Benefits to Patients in the United Kingdom: A Systematic Review of the Literature.Frontiers in digital health · 2021Pooled it
- Predictive Factors of Treatment Resistance in First Episode of Psychosis: A Systematic Review.Frontiers in psychiatry · 2019Pooled it
- Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A natural language processing analysis of electronic health records from 13,025 adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- First Episode Psychosis in Patients Aged 18 to 30 Admitted Involuntarily: Characteristics and Risk Factors for Functional Non-Remission.Brain sciences · 2025Article
- Presence of Psychotic Spectrum Symptoms Before Age 12 in Schizophrenia Patients: A Retrospective Study on Clinical Implications for Early Detection and Intervention.Brain sciences · 2025Article
- Article
- Challenges and opportunities in the diagnosis and treatment of early-onset psychosis: a case series from the youth affective disorders clinic in Stockholm, Sweden.Schizophrenia (Heidelberg, Germany) · 2024Article
- Recommended practices and ethical considerations for natural language processing-assisted observational research: A scoping review.Clinical and translational science · 2023Article
- A survey on clinical natural language processing in the United Kingdom from 2007 to 2022.NPJ digital medicine · 2022Review
- Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium.Schizophrenia research · 2022Article
- Article
- Individuals with schizophrenia who act violently towards others profit unequally from inpatient treatment-Identifying subgroups by latent class analysis.International journal of methods in psychiatric research · 2021Article
- Article
- Impact of the COVID-19 pandemic on remote mental healthcare and prescribing in psychiatry: an electronic health record study.BMJ open · 2021Article
- Using Natural Language Processing on Electronic Health Records to Enhance Detection and Prediction of Psychosis Risk.Schizophrenia bulletin · 2021Article
- Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis.Frontiers in psychiatry · 2021Article
- Toward the Development of Data Governance Standards for Using Clinical Free-Text Data in Health Research: Position Paper.Journal of medical Internet research · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The prevalence of negative symptoms (NS) at first episode of early-onset psychosis (EOP), and their effect on psychosis prognosis is unclear. In a sample of 638 children with EOP (aged 10-17 y, 51% male), we assessed (1) the prevalence of NS at first presentation to mental health services and (2) whether NS predicted eventual development of multiple treatment failure (MTF) prior to the age of 18 (defined by initiation of a third trial of novel antipsychotic due to prior insufficient response, intolerable adverse-effects or non-adherence). Data were extracted from the electronic health records held by child inpatient and community-based services in South London, United Kingdom. Natural Language Processing tools were used to measure the presence of Marder Factor NS and antipsychotic use. The association between presenting with ≥2 NS and the development of MTF over a 5-year period was modeled using Cox regression. Out of the 638 children, 37.5% showed ≥2 NS at first presentation, and 124 (19.3%) developed MTF prior to the age of 18. The presence of NS at first episode was significantly associated with MTF (adjusted hazard ratio 1.62, 95% CI 1.07-2.46; P = .02) after controlling for a number of potential confounders including psychosis diagnostic classification, positive symptoms, comorbid depression, and family history of psychosis. Other factors associated with MTF included comorbid autism spectrum disorder, older age at first presentation, Black ethnicity, and family history of psychosis. In EOP, NS at first episode are prevalent and may help identify a subset of children at higher risk of responding poorly to antipsychotics.
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