Evidence map›Paper›PMID 29370100›Full record

ReviewMolecules (Basel, Switzerland)2018

Chemical Modification of Chitosan for Efficient Vaccine Delivery.

Lei Xing, Ya-Tong Fan, Tian-Jiao Zhou, Jia-Hui Gong, Lian-Hua Cui, Ki-Hyun Cho, Yun-Jaie Choi, Hu-Lin Jiang, Chong-Su Cho

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Intranasal and intraperitoneal immunization againstClinical and experimental vaccine research · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. NiRSC advances · 2022
    Article
  17. Review
  18. PLGA Nanospheres as Delivery Platforms forFrontiers in immunology · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lei XingState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. xinglei6xl@163.com.
Ya-Tong FanState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. fyt2256@163.com.
Tian-Jiao ZhouState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. zhoutj1993@163.com.
Jia-Hui GongState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. gjh_cpu@yeah.net.
Lian-Hua CuiDepartment of Animal Science, College of Agriculture Science, Yanbian University, Yanji, Jilin 133002, China. cuilianhua@ybu.edu.cn.
Ki-Hyun ChoDepartment of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea. tea0353@naver.com.
Yun-Jaie ChoiDepartment of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea. cyjcow@snu.ac.kr.
Hu-Lin JiangState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. jianghulin3@163.com.
Chong-Su ChoDepartment of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea. chocs@snu.ac.kr.
China Pharmaceutical University · CNSeoul National University · KRYanbian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitosan, which exhibits good biocompatibility, safety, microbial degradation and other excellent performances, has found application in all walks of life. In the field of medicine, usage of chitosan for the delivery of vaccine is favored by a wide range of researchers. However, due to its own natural limitations, its application has been constrained to the beginning of study. In order to improve the applicability for vaccine delivery, researchers have carried out various chemical modifications of chitosan. This review summarizes a variety of modification methods and applications of chitosan and its derivatives in the field of vaccine delivery.

Indexed as

Drug Delivery SystemsAnimalsBiocompatible MaterialsChitosanDrug CarriersHumansHydrophobic and Hydrophilic InteractionsLigandsMolecular StructurePolyethylene GlycolsVaccinesVaccines, DNABiocompatible MaterialsChitosanDrug CarriersLigandsPolyethylene GlycolsVaccinesVaccines, DNAchemical modificationchitosanchitosan derivativesDNAvaccine

Identifiers

PMID29370100
PMCPMC6017229
OpenAlexW2791655169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.