Evidence map›Paper›PMID 29369918›Full record

ReviewCurrent opinion in endocrinology, diabetes, and obesity2018

Public health impact of androgens.

Gen Kanayama, Marc J Kaufman, Harrison G Pope

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in endocrinology, diabetes, and obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Impacts of Anabolic-androgenic steroid supplementation on female health and offspring: Mechanisms, side effects, and medical perspectives.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  3. Article
  4. Lived experiences of closeness to a person using Anabolic androgenic steroids a next of kin perspective.International journal of qualitative studies on health and well-being · 2024
    Article
  5. Article
  6. Article
  7. Reliability of Drug History to Verify Androgen Abuse in Men.The Journal of clinical endocrinology and metabolism · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Men´s experiences of using anabolic androgenic steroids.International journal of qualitative studies on health and well-being · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gen KanayamaDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Boston, Massachusetts, USA.
Marc J Kaufman
Harrison G Pope
McLean Hospital · US

Funding

Brain effects of long-term anabolic-androgenic steroid use:Multimodal imaging and cognition studiesR01DA041866 · NIDA · MCLEAN HOSPITAL · PI KAUFMAN, MARC J · 2017 to 2021
$2.8M
NIDA NIH HHS R01 DA041866
6 · The paper itself

Abstract

purpose of reviewTo summarize recent findings regarding the public health impact of androgen abuse. RECENT

findingsAbuse of androgens (also called 'anabolic-androgenic steroids') has grown into a major worldwide substance abuse problem involving tens of millions of individuals, of whom about 98% are men. Most androgen abusers are still under age 50 today, and thus, the long-term effects of these drugs are only beginning to be understood. Recent studies confirm that long-term supraphysiologic androgen exposure produces cardiovascular toxicity, characterized especially by cardiomyopathy and atherosclerotic disease. Withdrawal from androgens after long-term use may produce prolonged and sometimes irreversible hypogonadism in men. Supraphysiologic androgen levels may sometimes cause irritability, aggressiveness, and violence, whereas androgen withdrawal may cause depression. However, these psychiatric effects are idiosyncratic, affecting only a minority of users. Emerging evidence now also suggests that long-term androgen exposure may cause neurotoxicity, raising the possibility that aging androgen abusers may be at increased risk for dementia. Several recent studies have also described androgen-induced hepatotoxicity, nephrotoxicity, and adverse musculoskeletal effects. SUMMARY: Recent studies have demonstrated marked adverse effects of long-term androgen abuse. As increasing numbers of androgen abusers reach middle age, these effects will likely represent an emerging public health problem.

Indexed as

Public HealthAnabolic AgentsAndrogensCardiovascular DiseasesHumansHypogonadismMaleMental DisordersMiddle AgedNeurosecretory SystemsSubstance-Related DisordersAnabolic AgentsAndrogens

Identifiers

PMID29369918
PMCPMC6358207
OpenAlexW2791378338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.