Evidence map›Paper›PMID 29369482›Full record

ArticleJournal of cellular and molecular medicine2018

Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin α

Chih-Hsuan Hsia, Wan-Jung Lu, Kuan-Hung Lin, Duen-Suey Chou, Pitchairaj Geraldine, Thanasekaran Jayakuma, Nen-Chung Chang, Joen-Rong Sheu

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Suppression of Human Platelet Activation via Integrin αInternational journal of molecular sciences · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Chih-Hsuan HsiaGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-3999-9507
Wan-Jung LuDepartment of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.
Kuan-Hung LinCentral Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Duen-Suey ChouGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Pitchairaj GeraldineDepartment of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Thanasekaran JayakumaGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Nen-Chung ChangDepartment of Cardiology, Taipei Medical University Hospital, Taipei, Taiwan.
Joen-Rong SheuGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWTaipei Medical University Hospital · TWBharathidasan University · INMemorial Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During platelet activation, fibrinogen binds to its specific platelet receptor, integrin α

Indexed as

Adenosine TriphosphateAdultAntineoplastic AgentsBlood CoagulationBlood PlateletsBridged Bicyclo Compounds, HeterocyclicCell AdhesionEnzyme ActivationFibrinogenFocal Adhesion Protein-Tyrosine KinasesHumansL-Lactate DehydrogenasePlatelet AdhesivenessPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexProtective AgentsAdenosine TriphosphateAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicFibrinogenFocal Adhesion Protein-Tyrosine KinasesL-Lactate DehydrogenasenorcantharidinPlatelet Glycoprotein GPIIb-IIIa ComplexProtective AgentsP-SelectinSELP protein, humanantithrombosisfibrinogenintegrin αIIbβ3norcantharidinplatelet aggregation

Identifiers

PMID29369482
PMCPMC5867116
OpenAlexW2791778689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.