Evidence map›Paper›PMID 29369290›Full record

ArticleEar and hearing

Longitudinal Development of Distortion Product Otoacoustic Emissions in Infants With Normal Hearing.

Lisa L Hunter, Chelsea M Blankenship, Douglas H Keefe, M Patrick Feeney, David K Brown, Annie McCune, Denis F Fitzpatrick, Li Lin

Abstract read
In one paragraph

Article in Ear and hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lisa L HunterCincinnati Children's Hospital Medical Center, Communication Sciences Research Center, Cincinnati, Ohio, USA.
Chelsea M BlankenshipCincinnati Children's Hospital Medical Center, Communication Sciences Research Center, Cincinnati, Ohio, USA.
Douglas H KeefeBoys Town National Research Hospital, Omaha, Nebraska, USA.
M Patrick FeeneyPortland VA Medical Center, National Center for Rehabilitative Auditory Research, Portland, Oregon, USA.
David K BrownCincinnati Children's Hospital Medical Center, Communication Sciences Research Center, Cincinnati, Ohio, USA.
Annie McCuneDepartments of Otolaryngology and Communication Sciences and Disorders, University of Cincinnati, Cincinnati, Ohio, USA.
Denis F FitzpatrickBoys Town National Research Hospital, Omaha, Nebraska, USA.
Li LinCincinnati Children's Hospital Medical Center, Research in Patient Services, Cincinnati, Ohio, USA.
University of Cincinnati · USBoys Town National Research Hospital · USCincinnati Children's Hospital Medical Center · USPortland VA Medical Center · US

Funding

WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTIONR01DC010202 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI FEENEY, MARTIN PATRICK, HUNTER, LISA LEIGH · 2009 to 2013
$3.9M
NIDCD NIH HHS R01 DC010202
6 · The paper itself

Abstract

objectivesThe purpose of this study was to describe normal characteristics of distortion product otoacoustic emission (DPOAE) signal and noise level in a group of newborns and infants with normal hearing followed longitudinally from birth to 15 months of age.

designThis is a prospective, longitudinal study of 231 infants who passed newborn hearing screening and were verified to have normal hearing. Infants were enrolled from a well-baby nursery and two neonatal intensive care units (NICUs) in Cincinnati, OH. Normal hearing was confirmed with threshold auditory brainstem response and visual reinforcement audiometry. DPOAEs were measured in up to four study visits over the first year after birth. Stimulus frequencies f1 and f2 were used with f2/f1 = 1.22, and the DPOAE was recorded at frequency 2f1-f2. A longitudinal repeated-measure linear mixed model design was used to study changes in DPOAE level and noise level as related to age, middle ear transfer, race, and NICU history.

resultsSignificant changes in the DPOAE and noise levels occurred from birth to 12 months of age. DPOAE levels were the highest at 1 month of age. The largest decrease in DPOAE level occurred between 1 and 5 months of age in the mid to high frequencies (2 to 8 kHz) with minimal changes occurring between 6, 9, and 12 months of age. The decrease in DPOAE level was significantly related to a decrease in wideband absorbance at the same f2 frequencies. DPOAE noise level increased only slightly with age over the first year with the highest noise levels in the 12-month-old age range. Minor, nonsystematic effects for NICU history, race, and gestational age at birth were found, thus these results were generalizable to commonly seen clinical populations.

conclusionsDPOAE levels were related to wideband middle ear absorbance changes in this large sample of infants confirmed to have normal hearing at auditory brainstem response and visual reinforcement audiometry testing. This normative database can be used to evaluate clinical results from birth to 1 year of age. The distributions of DPOAE level and signal to noise ratio data reported herein across frequency and age in normal-hearing infants who were healthy or had NICU histories may be helpful to detect the presence of hearing loss in infants.

Indexed as

Otoacoustic Emissions, SpontaneousAudiometryCochleaEar, MiddleFemaleHearingHearing TestsHumansInfantInfant, NewbornLongitudinal StudiesMaleNoiseReference Values

Identifiers

PMID29369290
PMCPMC6056345
OpenAlexW2793098119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.