ArticleAIDS (London, England)2018
Substance-associated elevations in monocyte activation among methamphetamine users with treated HIV infection.
Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Who cites it
38 citing papers in PubMed, 49 citations in OpenAlex.
- A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine.Brain, behavior, and immunity · 2024Trial
- Blue Monday: Co-occurring Stimulant Use and HIV Persistence Predict Dysregulated Catecholamine Synthesis.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.Brain, behavior, and immunity · 2018Trial
- Integrating evidence-based methamphetamine interventions into methadone clinics: Structural barriers and implementation opportunities.The International journal on drug policy · 2026Article
- Longitudinal associations between depression, substance use, and immune activation and inflammation: A secondary analysis of men who have sex with men living with HIV in Brazil (HPTN 063).Brain, behavior, and immunity · 2026Article
- Smoldering in the sanctuary: HIV-associated brain injury in the ART era.The Journal of clinical investigation · 2026Review
- Quantifying brain-age gap in people with HIV on antiretroviral therapy using plasma neurofilament light chain.AIDS (London, England) · 2026Article
- Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles.Biomedicines · 2026Article
- Body talk: Correlates of gut-immune dysregulation phenotypes in people living with HIV who use methamphetamine.Brain, behavior, & immunity - health · 2026Article
- Article
- Stimulant Use, HIV, and Plasma Metabolites Among Men.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Intestinal barrier damage caused by addictive substance use disorder.European journal of medical research · 2025Review
- Neighborhood-level adversity and inflammation among sexual minority men living with HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders.Nanomedicine (London, England) · 2025Review
- Cannabis Use and Biomarkers of Inflammation, Immune Activation, and Microbial Translocation in Persons with HIV.Cannabis and cannabinoid research · 2024Article
- Structural Determinants of Health and Markers of Immune Activation and Systemic Inflammation in Sexual Minority Men With and Without HIV.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
- Overamped: Stimulant Use and HIV Pathogenesis.Current HIV/AIDS reports · 2023Review
- Longitudinal changes in neurocognitive performance related to drug use intensity in a sample of persons with and without HIV who use illicit stimulants.Drug and alcohol dependence · 2023Article
- Stimulant use, HIV, and immune dysregulation among sexual minority men.Drug and alcohol dependence · 2023Article
- No difference in COVID-19 treatment outcomes among current methamphetamine, cannabis and alcohol users.Journal of cannabis research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMicrobial translocation and monocyte activation predict mortality in treated HIV. We examined whether substance use independently contributes to these pathophysiologic processes.
designCross-sectional study at baseline for a randomized controlled trial.
methodsHIV-positive, methamphetamine-using MSM with undetectable HIV viral load (less than 40 copies/ml) were enrolled. We examined if plasma biomarkers of monocyte activation and intestinal barrier integrity were associated with the following: reactive urine toxicology results (Tox+) for stimulants (i.e., methamphetamine or cocaine) and substance use severity measured by the Addiction Severity Index. Multiple linear regression models adjusted for age, antiretroviral therapy regimen, CD4 T-cell count, interleukin-6, and alcohol use severity.
resultsThe sample of 84 virally suppressed MSM had a median CD4 T-cell count of 645 cells/μl. Those who were Tox+ for stimulants displayed higher soluble CD14 (sCD14) levels (2087 versus 1801 ng/ml; P = 0.009), and this difference remained significant after adjusting for covariates (standardized beta = 0.23, P = 0.026). Greater substance use severity was also independently associated with higher sCD14 after adjusting for covariates (standardized beta = 0.29, P = 0.013). Being Tox+ for stimulants and substance use severity were not associated with soluble CD163 (sCD163) or intestinal fatty acid binding protein (iFABP) levels (P > 0.05).
conclusionsMonocyte activation is one plausible mechanism by which stimulant use may increase clinical HIV progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.