Evidence map›Paper›PMID 29369158›Full record

ArticleAIDS (London, England)2018

The growing burden of noncommunicable disease among persons living with HIV in Zimbabwe.

Mikaela Smit, Jack Olney, Nathan P Ford, Marco Vitoria, Simon Gregson, Anna Vassall, Timothy B Hallett

Abstract read
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  17. Interventions for Type 2 Diabetes reduction among older people living with HIV in Harare.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikaela SmitDepartment of Infectious Disease Epidemiology, Faculty of Medicine at St Mary's Campus, Imperial College London, London, UK.
Jack OlneyDepartment of Infectious Disease Epidemiology, Faculty of Medicine at St Mary's Campus, Imperial College London, London, UK.
Nathan P FordDepartment of HIV/AIDS and Global Hepatitis Programme, World Health Organisation, Geneva, Switzerland.
Marco VitoriaDepartment of HIV/AIDS and Global Hepatitis Programme, World Health Organisation, Geneva, Switzerland.
Simon GregsonDepartment of Infectious Disease Epidemiology, Faculty of Medicine at St Mary's Campus, Imperial College London, London, UK.
Anna VassallDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Timothy B HallettDepartment of Infectious Disease Epidemiology, Faculty of Medicine at St Mary's Campus, Imperial College London, London, UK.

Funding

Multi-Level Behavioral Economics and Community Psychology Approaches to Strengthen HIV Prevention Cascades in Adolescent Girls and Young Women in East ZimbabweR01MH114562 · NIMH · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI GREGSON, SIMON ANTHONY JOHN, HALLETT, TIMOTHY · 2017 to 2020
$2.6M
Quantify and prepare for the double infectious and non-communicable disease burden in Zimbabwe.R21AG053093 · NIA · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI HALLETT, TIMOTHY · 2016 to 2017
$288k
NIA NIH HHS R21 AG053093NIMH NIH HHS R01 MH114562World Health Organization 001
6 · The paper itself

Abstract

objectivesWe aim to characterize the future noncommunicable disease (NCD) burden in Zimbabwe to identify future health system priorities.

methodsWe developed an individual-based multidisease model for Zimbabwe, simulating births, deaths, infection with HIV and progression and key NCD [asthma, chronic kidney disease (CKD), depression, diabetes, hypertension, stroke, breast, cervical, colorectal, liver, oesophageal, prostate and all other cancers]. The model was parameterized using national and regional surveillance and epidemiological data. Demographic and NCD burden projections were generated for 2015 to 2035.

resultsThe model predicts that mean age of PLHIV will increase from 31 to 45 years between 2015 and 2035 (compared with 20-26 in uninfected individuals). Consequently, the proportion suffering from at least one key NCD in 2035 will increase by 26% in PLHIV and 6% in uninfected. Adult PLHIV will be twice as likely to suffer from at least one key NCD in 2035 compared with uninfected adults; with 15.2% of all key NCDs diagnosed in adult PLHIV, whereas contributing only 5% of the Zimbabwean population. The most prevalent NCDs will be hypertension, CKD, depression and cancers. This demographic and disease shift in PLHIV is mainly because of reductions in incidence and the success of ART scale-up leading to longer life expectancy, and to a lesser extent, the cumulative exposure to HIV and ART.

conclusionNCD services will need to be expanded in Zimbabwe. They will need to be integrated into HIV care programmes, although the growing NCD burden amongst uninfected individuals presenting opportunities for additional services developed within HIV care to benefit HIV-negative persons.

Indexed as

AdultAgedAged, 80 and overComorbidityComputer SimulationFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedModels, StatisticalNoncommunicable DiseasesYoung AdultZimbabwe

Identifiers

PMID29369158
PMCPMC5856639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.