Evidence map›Paper›PMID 29368662›Full record

ArticleSystematic reviews2018

Treatment outcomes in patients with opioid use disorder initiated by prescription: a systematic review protocol.

Nitika Sanger, Meha Bhatt, Laura Zielinski, Stephanie Sanger, Hamnah Shahid, Bianca Bantoto, M Constantine Samaan, Russell de Souza, Zainab Samaan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nitika SangerMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Meha BhattDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Laura ZielinskiDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Stephanie SangerHealth Science Library, McMaster University, Hamilton, ON, Canada.
Hamnah ShahidArts & Sciences, McMaster University, Hamilton, ON, Canada.
Bianca BantotoIntegrated Sciences Program, McMaster University, Hamilton, ON, Canada.
M Constantine SamaanMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Russell de SouzaMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Zainab SamaanMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada. samaanz@mcmaster.ca.ORCID 0000-0002-5974-9361
McMaster University · CAImpact · CAMcMaster Children's Hospital · CAMcMaster University Medical Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn North America, opioid use has become a public health crisis with policy makers declaring it a state of emergency. Opioid substitution therapy (OST) is a harm-reduction method used in treating opioid use disorder. While OST has shown to be successful in improving treatment outcomes, there is still a great degree of variability among patients. This cohort of patients has shifted from young males using heroin to a greater number of older people and women using prescription opioids. The primary objective of this review is to examine the literature on the association between the first exposure to opioids through prescription versus illicit use and OST treatment outcomes.

methodAn electronic search will be conducted on the EMBASE, MEDLINE, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. Two independent reviewers will conduct the initial title and abstract screenings using predetermined criteria for inclusion and exclusion. Reviewers will then conduct full-text data extraction using a pilot-tested data extraction form in duplicate. A third author will resolve disagreements if consensus cannot be reached. Quality and risk of bias assessment will be conducted along with a sensitivity analysis for all included studies. Qualitative summary of the evidence will be provided, and when possible, a meta-analysis will be conducted, along with heterogeneity calculation. The reporting of this protocol follows the PRISMA-P. DISCUSSION: We expect that this review will help determine whether patients that were initially exposed to opioids through a prescription differ in OST treatment outcomes in comparison to people who used opioids through illicit means. We hope that this review will provide evidence related to prescription opioids exposure and future treatment outcomes, which will aid clinicians in their decisions to prescribe opioids or not for specific populations at risk. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017058143.

Indexed as

Analgesics, OpioidIllicit DrugsMethadoneOpioid-Related DisordersPrescription DrugsHumansMeta-Analysis as TopicNorth AmericaOpiate Substitution TreatmentPractice Patterns, Physicians'Systematic Reviews as TopicAnalgesics, OpioidIllicit DrugsMethadonePrescription DrugsOpioid substitution therapyOpioid use disorderOSTPrescription opioidsProtocolSystematic review

Identifiers

PMID29368662
PMCPMC5784712
OpenAlexW2784605569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.