ArticleCardiovascular diabetology2018
Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus.
Article in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Depression and cardiovascular disease events among patients with type 2 diabetes: A systematic review and meta-analysis with bias analysis.Journal of diabetes and its complications · 2020Pooled it
- Psychosocial burden of cardiac patients: a retrospective in-patient analysis.BMC cardiovascular disorders · 2026Article
- Cardiovascular Disease, Depressive Symptoms, and Heart Failure in Mexican American Aged 75 Years and Older During 12 Years of Follow Up.Journal of affective disorders reports · 2024Article
- Validation of Chinese version of the 5-item WHO well-being index in type 2 diabetes mellitus patients.BMC psychiatry · 2023Article
- Depressive Symptoms and Incident Hospitalization for Heart Failure: Findings From the REGARDS Study.Journal of the American Heart Association · 2022Article
- Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022Review
- FKN/NR Signaling Pathway Regulates Hippocampal Inflammatory Responses: the Survival of Hippocampal Neurons in Diabetic Rats with Chronic Unpredictable Mild Stress.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population.Global heart · 2022Article
- Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats.Frontiers in cell and developmental biology · 2021Article
- Outcome assessment using estimation of left ventricular filling pressure in asymptomatic patients at risk for heart failure with preserved ejection fraction.International journal of cardiology. Heart & vasculature · 2020Article
- Article
- Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus.Clinical cardiology · 2019Article
- Bi-directional association between depression and HF: An electronic health records-based cohort study.Journal of comorbidityArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDepression is a prevalent, independent predictor of mortality in patients with heart failure (HF). Depression is also common in type 2 diabetes mellitus (T2DM), which is itself an important risk factor for HF. However, association of depression with incident HF in T2DM is undefined. The aim of the present study was to evaluate the predictive value of depression in predicting incident HF in a community-based cohort of asymptomatic patients with T2DM.
methodsWe prospectively recruited 274 asymptomatic T2DM patients ≥ 65 years (age 71 ± 4 year, 56% men) with preserved EF and no ischemic heart disease from a community-based population. The Patient Health Questionnaire 9 (PHQ-9) was used to detect depression, and LV dysfunction was sought with a comprehensive echocardiogram, including LV hypertrophy (LVH) and subclinical diastolic function (E/e'). Over a median follow-up of 1.5 years (range 0.5-3), 20 patients were lost to follow-up and 254 individuals were followed for outcomes.
resultsAt baseline, depression was present in 9.5%, LVH was identified in 26% and reduced E/e' in 11%. Over a median follow-up of 1.5 years, 37 of 245 patients developed new-onset HF and 3 died, giving an event rate of 107/1000 person-years. In a competing-risks regression analysis, depression (adjusted HR 2.54, 95% CI 1.18-5.46; p = 0.017) was associated with incident HF and had incremental predictive power to clinical, biochemical and echocardiographic variables.
conclusionDepression is prevalent in asymptomatic elderly patients with T2DM, and depression independently and incrementally predicts incident HF.
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