ArticleBMC pulmonary medicine2018
Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study.
Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Pharmacological mechanism of roflumilast in the treatment of asthma-COPD overlap.Drug design, development and therapy · 2018Pooled it
- Patterns of Comorbidity in Asthma-COPD Overlap Cohort According to Various ACO Definitions.Advances in respiratory medicine · 2026Article
- Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria.Journal of pharmaceutical policy and practice · 2026Review
- Hospitalization Outcomes of Patients with Asthma, COPD, and Asthma-COPD Overlap Syndrome.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- COVID-19 and Long-term Risk of Ischemic Heart Disease in Asthma.Allergy, asthma & immunology research · 2025Article
- Fatigue, Depression, and Anxiety in Patients with COPD, Asthma and Asthma-COPD Overlap.Journal of clinical medicine · 2022Article
- Article
- The effects of medications for treating COPD and allied conditions on stroke: a population-based cohort study.NPJ primary care respiratory medicine · 2022Article
- Asthma Therapies on Pulmonary Tuberculosis Pneumonia in Predominant Bronchiectasis-Asthma Combination.Frontiers in pharmacology · 2022Article
- Long-Term Survival and Medical Costs of Patients with Prolonged Mechanical Ventilation and Tracheostomy: A Nationwide Cohort Study.International journal of environmental research and public health · 2021Article
- Long-term prognosis of new adult-onset asthma in obese patients.The European respiratory journal · 2021Article
- Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study.NPJ primary care respiratory medicine · 2021Article
- Association of socioeconomic deprivation with asthma care, outcomes, and deaths in Wales: A 5-year national linked primary and secondary care cohort study.PLoS medicine · 2021Article
- Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma-COPD Overlap in vivo and in vitro.Journal of inflammation research · 2021Article
- Article
- Associations among chronic obstructive pulmonary disease with asthma, pneumonia, and corticosteroid use in the general population.PloS one · 2020Observational
- Fungal Diseases in Taiwan-National Insurance Data and Estimation.Journal of fungi (Basel, Switzerland) · 2019Article
- Association between continuity of care and emergency department visits and hospitalization in senior adults with asthma-COPD overlap.Health policy (Amsterdam, Netherlands) · 2019Article
- Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study.Frontiers in pharmacology · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with symptoms of both asthma and chronic obstructive pulmonary disease (COPD) may be classified with the term asthma-COPD overlap (ACO). ACO is of considerable interest as it is currently poorly characterised and has been associated with worse health outcomes and higher healthcare costs compared with COPD or asthma alone. Patients with ACO in Asia remain poorly described, and there is limited information regarding their resource utilisation compared with patients with asthma or COPD only. This study investigated the characteristics, disease burden and medical resource utilisation of patients with ACO in Taiwan.
methodsThis was a retrospective cohort study of patients identified from National Health Insurance (NHI) claims data in Taiwan in 2009-2011. Patients were classified into incident ACO, COPD or asthma cohorts according to International Classification of Disease, ninth revision, clinical modification codes in claims. Eligible patients were ≥40 years of age with 12 months' continuous enrolment in the NHI programme pre- and post-index date (date of the first relevant medical claim).
resultsPatients with ACO (N = 22,328) and COPD (N = 69,648) were older and more likely to be male than those with asthma (N = 50,293). Patients with ACO had more comorbidities and exacerbations, with higher medication use: short-acting β
conclusionsPatients with ACO in Taiwan experience a greater disease burden with greater healthcare resource utilisation, and higher costs, than patients with asthma or COPD alone.
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