Evidence map›Paper›PMID 29368599›Full record

Trial reportBMC pulmonary medicine2018

Effectiveness of nasal highflow in hypercapnic COPD patients is flow and leakage dependent.

Jens Bräunlich, Friederike Mauersberger, Hubert Wirtz

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02504814 nacompletednot on this map

Physiological and Clinical Changes in NHF Therapy

TypeinterventionalSponsorUniversity of LeipzigRan2011 to 2018Enrolled64ConditionsChronic Obstructive Pulmonary Disease, Hypercapnia, Interstitital Lung DiseaseArmsNasal Highflow (NHF)
NCT04655638 nacompletednot on this mapstarted 2021, after this paper: background citation

High-Flow Nasal Therapy Versus Conventional Oxygen Therapy in Patients With COVID-19: A Randomized Controlled Trial (The COVID-HIGH Trial)

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoRan2021 to 2021Enrolled364ConditionsCovid19, Acute Respiratory FailureArmsHigh Flow Nasal Therapy, Conventional Oxygen Therapy
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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  11. Development in PaCOBMJ open respiratory research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jens BräunlichDepartment of Respiratory Medicine, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. jens.braeunlich@uniklinik-leipzig.de.ORCID http://orcid.org/0000-0002-6147-6366
Friederike MauersbergerDepartment of Respiratory Medicine, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Hubert WirtzDepartment of Respiratory Medicine, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Leipzig University · DELeipzig University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary data suggest that NHF may decrease hypercapnia in hypercapnic respiratory failure. The aim of this study was to evaluate the mechanism of NHF mediated PCO

methodsIn 36 hypercapnic COPD patients (PCO

resultsHypercapnia significantly decreased in all patients. In patients with capillary PCO

conclusionsThis study demonstrates effective PCO

trial registrationClinical Trials: NCT02504814; First posted July 22, 2015.

Indexed as

AgedBlood Gas AnalysisCannulaCarbon DioxideFemaleHumansHypercapniaMaleMiddle AgedNoninvasive VentilationNosePartial PressureProspective StudiesPulmonary Disease, Chronic ObstructiveCarbon DioxideCOPDHypercapniaNasal high flowType II respiratory failureWash-out

Identifiers

PMID29368599
PMCPMC5784698
OpenAlexW2790873419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.