ArticleBMC evolutionary biology2018
Widespread signatures of selection for secreted peptidases in a fungal plant pathogen.
Article in BMC evolutionary biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
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- Functional genome analysis reveals that serine carboxypeptidaseFrontiers in plant science · 2025Article
- Comparative Genomics Reveals Sources of Genetic Variability in the Asexual Fungal Plant Pathogen Colletotrichum lupini.Molecular plant pathology · 2024Article
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- Genome-Wide Association Study Reveals Novel Powdery Mildew Resistance Loci in Bread Wheat.Plants (Basel, Switzerland) · 2023Article
- Large-scale genomic analyses with machine learning uncover predictive patterns associated with fungal phytopathogenic lifestyles and traits.Scientific reports · 2023Article
- Secretome Analysis for a New Strain of the Blackleg FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Dual RNA-Seq Profiling Unveils Mycoparasitic Activities ofMicrobiology spectrum · 2023Article
- Secretomic Insights into the Pathophysiology ofPathogens (Basel, Switzerland) · 2022Article
- An in-planta comparative study of Plasmopara viticola proteome reveals different infection strategies towards susceptible and Rpv3-mediated resistance hosts.Scientific reports · 2022Article
- Genome-Wide Association Mapping of Virulence Genes in Wheat Karnal Bunt FungusFrontiers in microbiology · 2022Article
- Genetic response to nitrogen starvation in the aggressive Eucalyptus foliar pathogen Teratosphaeria destructans.Current genetics · 2021Article
- Population-level deep sequencing reveals the interplay of clonal and sexual reproduction in the fungal wheat pathogenMicrobial genomics · 2021Article
- Chitosan modulates Pochonia chlamydosporia gene expression during nematode egg parasitism.Environmental microbiology · 2021Article
- Rapid sequence evolution driven by transposable elements at a virulence locus in a fungal wheat pathogen.BMC genomics · 2021Article
- Defense and Offense Strategies: The Role of Aspartic Proteases in Plant-Pathogen Interactions.Biology · 2021Review
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Necrotrophic lifestyle of Rhizoctonia solani AG3-PT during interaction with its host plant potato as revealed by transcriptome analysis.Scientific reports · 2020Article
- Bioinformatic Detection of Positive Selection Pressure in Plant Pathogens: The Neutral Theory of Molecular Sequence Evolution in Action.Frontiers in microbiology · 2020Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFungal plant pathogens secrete a large arsenal of hydrolytic enzymes during the course of infection, including peptidases. Secreted peptidases have been extensively studied for their role as effectors. In this study, we combined transcriptomics, comparative genomics and evolutionary analyses to investigate all 39 secreted peptidases in the fungal wheat pathogen Zymoseptoria tritici and its close relatives Z. pseudotritici and Z. ardabiliae.
resultsRNA-seq data revealed that a majority of the secreted peptidases displayed differential transcription during the course of Z. tritici infection, indicative of specialization for different stages in the life cycle. Evolutionary analyses detected widespread evidence of adaptive evolution acting on at least 28 of the peptidases. A few peptidases displayed lineage-specific rates of molecular evolution, suggesting altered selection pressure in Z. tritici following host specialization on domesticated wheat. The peptidases belonging to MEROPS families A1 and G1 emerged as a particularly interesting group that may play key roles in host-pathogen co-evolution, host adaptation and pathogenicity. Sister genes in the A1 and G1 families showed accelerated substitution rates after gene duplications.
conclusionsThese results suggest widespread evolution of secreted peptidases leading to novel gene functions, consistent with predicted models of "escape from adaptive conflict" and "neo-functionalization". Our analyses identified candidate genes worthy of functional analyses that may encode effector functions, for example by suppressing plant defenses during the biotrophic phase of infection.
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