Evidence map›Paper›PMID 29368532›Full record

ArticleScandinavian journal of gastroenterology2018

Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease.

Neil D Parikh, Artur V Viana, Saloni Shah, Loren Laine

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Scandinavian journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. A Deep Learning Model for Classification of Endoscopic Gastroesophageal Reflux Disease.International journal of environmental research and public health · 2021
    Article
  4. Is Noncardiac Chest Pain Truly Noncardiac?Clinical Medicine Insights. Cardiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Neil D Parikha Section of Digestive Diseases , Yale School of Medicine , New Haven , CT , USA.
Artur V Vianaa Section of Digestive Diseases , Yale School of Medicine , New Haven , CT , USA.
Saloni Shahc Northeastern University , Boston , MA , USA.
Loren Lainea Section of Digestive Diseases , Yale School of Medicine , New Haven , CT , USA.
Yale University · USNortheastern University · USVA Connecticut Healthcare System · US

Funding

Training Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
NIDDK NIH HHS T32 DK007017NIDDK NIH HHS T32 DK007356
6 · The paper itself

Abstract

objectivesWe assessed the performance characteristics of image-enhanced endoscopy with i-Scan or narrow band imaging (NBI) in patients with non-erosive gastroesophageal reflux disease (GERD) compared to controls without heartburn. MATERIAL AND

methodsImage-enhanced endoscopic findings of vascularity at the squamocolumnar junction, distal esophageal micro-erosions, and non-round pit pattern at the squamocolumnar junction were assessed in cases (heartburn not responsive to PPIs, positive results on validated GERD questionnaire, no esophageal erosions, esophageal biopsies with histologic evidence of GERD (basal cell hyperplasia, elongation of papillae and dilation of intercellular spaces all required)) and in controls (no GERD symptoms or esophageal erosions).

resultsTwenty cases and 60 controls were compared. The pre-defined features were more common in cases vs. CONTROLS: vascularity RR = 4.9 (95% CI: 2.4-10.0), specificity = 86.7%; micro-erosions RR = 9.7 (3.6-26.5), specificity = 93.3%; non-round pit pattern RR = 2.4 (1.7-3.3), specificity = 60.0%; combination of vascularity and micro-erosions RR = 30.0 (4.1-220), specificity = 98.3%. These differences were consistent with both i-Scan and NBI.

conclusionsImage-enhanced endoscopic findings of vascularity and micro-erosions were very specific for non-erosive GERD. Image-enhanced endoscopy may be useful in real-time diagnosis of non-erosive GERD when patients undergo upper endoscopy for heartburn. The relative utility of image-enhanced endoscopy vs. pH-impedance monitoring, based on efficacy, cost and patient acceptance, requires additional study.

Indexed as

Endoscopy, GastrointestinalImage EnhancementAdultAgedAged, 80 and overCase-Control StudiesEsophagusFemaleGastroesophageal RefluxHeartburnHumansMaleMiddle AgedNarrow Band ImagingProspective StudiesSensitivity and SpecificityendoscopyGastroesophageal refluxgastrointestinalheartburnimage enhancement

Identifiers

PMID29368532
PMCPMC6080852
OpenAlexW2792374319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.