ArticleCNS neuroscience & therapeutics2018
Incapacity to control emotion in major depression may arise from disrupted white matter integrity and OFC-amygdala inhibition.
Article in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Detection of white matter microstructural changes in patients with systemic lupus erythematosus based on multiple diffusion models and related diffusion metrics.Neural regeneration research · 2026Article
- Beyond depression symptoms: the default mode network as a predictor of antidepressant response.Npj mental health research · 2026Article
- Neural evidence for exercise-driven emotional stability via cognitive regulation mechanisms.Frontiers in psychology · 2026Article
- Review
- Intracranial directed connectivity links subregions of the prefrontal cortex to major depression.Nature communications · 2025Article
- Paranode length in the prefrontal cortex of subjects with major depression and rats under chronic unpredictable stress.Journal of affective disorders · 2025Article
- Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.EBioMedicine · 2024Article
- A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Intracranial Directed Connectivity Links Subregions of the Prefrontal Cortex to Major Depression.medRxiv : the preprint server for health sciences · 2024Article
- Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study.IBRO neuroscience reports · 2024Article
- Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Executive function, limbic circuit dynamics and repetitive and restricted behaviors in children with autism spectrum disorder.Frontiers in neuroscience · 2024Article
- Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders.Journal of psychiatry and brain science · 2023Article
- White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.Depression and anxiety · 2022Article
- Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit.Brain structure & function · 2022Article
- Personalized Diagnosis and Treatment for Neuroimaging in Depressive Disorders.Journal of personalized medicine · 2022Review
- White matter integrity in adolescent irritability: A preliminary study.Psychiatry research. Neuroimaging · 2022Article
- Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response.CNS neuroscience & therapeutics · 2022Article
- Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome.Translational psychiatry · 2021Review
- White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.Neuroscience · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisturbances in emotion regulation are the hallmarks of major depressive disorder (MDD). The incapacity to control negative emotion in patients has been associated with abnormal hyperactivation of the limbic system and hypoactivation of the frontal cortex. The amygdala and orbital frontal cortex (OFC) are two critical regions of the emotion regulation neural systems.
methodsThis study investigated the anatomical basis of abnormal emotion regulation by tracking the fiber tracts connecting the amygdala and OFC. In addition, using dynamic casual modeling on resting-state fMRI data of 20 MDD patients and equivalent controls, we investigated the exact neural mechanism through which abnormal communications between these two nodes were mediated in MDD. KEY
resultsThe results revealed disrupted white matter integrity of fiber tracts in MDD, suggesting that functional abnormalities were accompanied by underlying anatomical basis. We also detected a failure of inhibition of the OFC on the activity of the amygdala in MDD, suggesting dysconnectivity was mediated through "top-down" influences from the frontal cortex to the amygdala. Following 8 weeks of antidepressant treatment, the patients showed significant clinical improvement and normalization of the abnormal OFC-amygdala structural and effective connectivity in the left hemisphere. CONCLUSIONS & INFERENCES: Our findings suggest that pathways connecting these two nodes may be core targets of the antidepressant treatment. In particular, it raised the intriguing question: Does the reversal of structural markers of connectivity reflect a response to antidepressant medication or activity-dependent myelination following a therapeutic restoration of effective connectivity?
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