Evidence map›Paper›PMID 29368397›Full record

ArticlePhysiological reports2018

l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain.

Keita Kanzaki, Daiki Watanabe, Chihiro Aibara, Yuki Kawakami, Takashi Yamada, Yoshitaka Takahashi, Masanobu Wada

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Keita KanzakiDepartment of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan.
Daiki WatanabeGraduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.
Chihiro AibaraGraduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.
Yuki KawakamiDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan.
Takashi YamadaGraduate School of Health Sciences, Sapporo Medical University, Hokkaido, Japan.
Yoshitaka TakahashiDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan.
Masanobu WadaGraduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.
Hiroshima University · JPOkayama Prefectural University · JPKawasaki University of Medical Welfare · JPSapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown that calpains are involved in the proteolysis of muscle proteins that occurs with eccentric contraction (ECC) and that exogenously applied nitric oxide decreases the calpain-mediated proteolysis. The aim of this study was to examine the effects of ingestion of l-arginine (ARG), a nitric oxide precursor, on ECC-related calpain activation. In the first and second experiments, male Wistar rats were given ARG in water for 7 days starting from 3 days before the ECC protocol (average ingestion, ~600 mg kg-body wt

Indexed as

AnimalsArginineCalpainMaleMuscle ContractionMuscle, SkeletalProteolysisRatsRats, WistarArginineCalpainCa2+ regulatory proteinsnitric oxideNO synthasesarcoplasmic reticulum

Identifiers

PMID29368397
PMCPMC5789731
OpenAlexW2793083777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.