ReviewJournal of nephrology2018
Hyperuricosuric calcium urolithiasis.
Review in Journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Relationship Between theFrontiers in genetics · 2020Pooled it
- Brazilian Guidelines on evaluation and clinical management of Nephrolithiasis: Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- The Role of Altered Mineral Metabolism in Kidney Stone Disease: Is Vitamin D the Key?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- CaSR regulates SLC26A6 expression via the PKA-FOXO4 signaling axis to promote experimental calcium oxalate kidney stone formation in rats.Frontiers in cell and developmental biology · 2026Article
- Serum calcium-magnesium-phosphate-potassium metabolic dysregulation in nephrolithiasis: predictive model development and mechanistic insights.Frontiers in physiology · 2026Article
- Association of insulin resistance indices with kidney stones and their recurrence in a non-diabetic population: an analysis based on NHANES data from 2007-2018.Renal failure · 2025Article
- Kidney stone disease: risk factors, pathophysiology and management.Nature reviews. Nephrology · 2025Review
- Review
- A Fresh Look at Oral Chemolysis for Non-Symptomatic Kidney Stones-Comparative Research of Potassium Citrate and Allopurinol Combination-Is Treatment Possible Without Stone Analysis?Journal of clinical medicine · 2025Article
- 24-Hour Urinary Chemistries and Kidney Stone Risk.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- The Impact of Urate-Lowering Therapy in Post-Myocardial Infarction Patients: Insights From a Population-Based, Propensity Score-Matched Analysis.Clinical pharmacology and therapeutics · 2022Article
- Numerical characterization of astronaut CaOx renal stone incidence rates to quantify in-flight and post-flight relative risk.NPJ microgravity · 2022Article
- Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs.Journal of veterinary internal medicine · 2022Article
- Calcium oxalate urolithiasis in juvenile dogs.The Veterinary record · 2021Article
- Association between metabolic syndrome and calcium oxalate stone risk in Chinese individuals: a nomogram prediction model.The Journal of international medical research · 2021Article
- Uric Acid and Urate in Urolithiasis: The Innocent Bystander, Instigator, and Perpetrator.Seminars in nephrology · 2020Review
- Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian-Vegan Diets.Nutrients · 2020Review
- Meeting report of the "Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017".Journal of nephrology · 2019Article
- Decreased Associated Risk of Gout in Diabetes Patients with Uric Acid Urolithiasis.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Hyperuricosuric calcium urolithiasis is a condition of mixed calcium oxalate stones characterized by hyperuricosuria either in isolation or in conjunction with other risk factors for calcium oxalate stones such as hypercalciuria, hyperoxaluria, and hypocitraturia. There are three proposed physicochemical models of pathogenesis where urate in its crystalline phase via heterogeneous nucleation, in its colloidal phase via removal of crystallization inhibitors, and in solution via precipitation crystallization, can all increase propensity to calcium oxalate precipitation. Regardless of the model, the phenomenologic observation of urate increasing calcium oxalate precipitation appears solid. Another supporting factor are retrospective data analysis and prospective trials showing uric acid lowering reduces stones events in hyperuricosuric calcium stone formers. Due to the heterogeneity of pathogenesis of calcium oxalate stones in the unselected stone-formers, association cannot be demonstrated between uric acid excretion rate and risk of kidney stone the general population. In calcium oxalate stoners with isolated hyperuricosuria or hyperuricosuria in combination with other calcium stone risks where treatment of these traditional risks fails to reduce stone formation, urate acid lowering should be cautiously attempted. More refinement of pathogenic models and prospective controlled trials in phenotypically defined subgroups of subjects with calcium oxalate urolithiasis will be informative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.