Evidence map›Paper›PMID 29368147›Full record

ArticleArchives of toxicology2018

Cytochrome b

Lindsay Reed, Iveta Mrizova, Frantisek Barta, Radek Indra, Michaela Moserova, Klaus Kopka, Heinz H Schmeiser, C Roland Wolf, Colin J Henderson, Marie Stiborova and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Archives of toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. The toxic effects ofFood science & nutrition · 2024
    Article
  2. Article
  3. Metabolic Activation of Benzo[International journal of molecular sciences · 2022
    Article
  4. Article
  5. Benzo[International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
  8. Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase.Mutation research. Genetic toxicology and environmental mutagenesis · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Application of hepatic cytochrome bToxicology and applied pharmacology · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Lindsay ReedDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
Iveta MrizovaDepartment of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic.
Frantisek BartaDepartment of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic.
Radek IndraDepartment of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic.
Michaela MoserovaDepartment of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic.
Klaus KopkaDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Heinz H SchmeiserDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
C Roland WolfDivision of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK.
Colin J HendersonDivision of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK.
Marie StiborovaDepartment of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic.
David H PhillipsDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.ORCID http://orcid.org/0000-0001-8509-3485
Volker M ArltDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. volker.arlt@kcl.ac.uk.ORCID http://orcid.org/0000-0003-4314-9318
Charles University · CZKing's College London · GBGerman Cancer Research Center · DEUniversity of Dundee · GB

Funding

Cancer Research UK 10822Cancer Research UK 22357Cancer Research UK C313/A14329Cancer Research UK C4639/A10822Medical Research Council 1524896Wellcome TrustWellcome Trust 101126/B/13/ZWellcome Trust 101126/Z/13/Z
6 · The paper itself

Abstract

Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cytochrome b

Indexed as

AnimalsBenzo(a)pyreneCytochrome-B(5) ReductaseDNA AdductsHepatocytesMiceMice, KnockoutMicrosomes, LiverNADPH-Ferrihemoprotein ReductaseBenzo(a)pyrenebenzo(a)pyrene-DNA adductCytochrome-B(5) ReductaseDNA AdductsNADPH-Ferrihemoprotein Reductase

Identifiers

PMID29368147
PMCPMC5882632
OpenAlexW2784370974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.