ArticleClinical research in cardiology : official journal of the German Cardiac Society2018
The 6MWT as a prognostic tool in pulmonary arterial hypertension: results from the COMPERA registry.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01347216 (Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension
Who cites it
25 citing papers in PubMed.
- Prognostic value of baseline and longitudinal changes in exercise capacity and quality of life in the HF-Wii Swedish population.Open heart · 2026Trial
- Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Individually tailored home-based physiotherapy program makes sustainable improvement in exercise capacity and daily physical activity in patients with pulmonary arterial hypertension.Therapeutic advances in respiratory diseaseTrial
- Remote exercise assessment in pulmonary hypertension.Current opinion in pulmonary medicine · 2026Review
- Article
- Clinical relevance of the TAPSE/SPAP ratio in pulmonary arterial hypertension: a single-center retrospective study.BMC cardiovascular disorders · 2026Article
- Six-minute walk distance predicting the risk of mortality in lymphangioleiomyomatosis patients.Orphanet journal of rare diseases · 2026Article
- Response to Letter to the Editor: Effectiveness of Early Cardiorespiratory Rehabilitation Combined With Melatonin Supplementation During the Inpatient Period After Acute Myocardial Infarction: a Pilot Study.Archives of rehabilitation research and clinical translation · 2025Article
- The Efficacy and Safety of Outpatient Exercise Training for Patients with Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty.Journal of cardiovascular development and disease · 2025Article
- Risk stratification and treatment goals in pulmonary arterial hypertension.The European respiratory journal · 2024Review
- Usefulness of the Duke Activity Status Index to Assess Exercise Capacity and Predict Risk Stratification in Patients with Pulmonary Arterial Hypertension.Journal of clinical medicine · 2023Article
- Time to clinical improvement: an appropriate surrogate endpoint for pulmonary arterial hypertension medication trials.Frontiers in cardiovascular medicine · 2023Article
- Carbon Monoxide Diffusion Capacity as a Severity Marker in Pulmonary Hypertension.Journal of clinical medicine · 2021Article
- Effects of WeChat platform-based health management on health and self-management effectiveness of patients with severe chronic heart failure.World journal of clinical cases · 2021Article
- Daily Step Counts Are Associated with Hospitalization Risk in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2021Article
- Flow-Mediated Dilation, a Marker of Endothelial Cell Dysfunction, in Patients with Pulmonary Hypertension.Tanaffos · 2021Article
- A challenging case of severe pulmonary bleeding in a patient with congenital ventricular septal defect (VSD) and Eisenmenger syndrome: extracorporeal membrane oxygenation (ECMO) support and weaning strategies.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Heart Rate Expenditure Correlates with Right Ventricular Function.Annals of the American Thoracic Society · 2020Article
- Review
- Portopulmonary Hypertension: From Bench to Bedside.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundIn patients with pulmonary arterial hypertension, the 6-Minute Walk Test (6MWT) is recommended for risk stratification and follow-up by all guidelines. However, the prognostic value of the 6MWT has been discussed controversially. We sought to compare and validate all published 6MWT cut-off points.
methodsFrom the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)-registry we identified 2391 patients with pulmonary arterial hypertension who had at least one documented 6MWT measurement. A Medline search identified a total of 21 different threshold values for either single-point or change of 6MWT. All values were tested individually for prognostication of 1-year, 2-year and 3-year all-cause mortality.
resultsThe highest positive likelihood ratio was a cut-off value < 165 ms, whereas the best negative likelihood ratio was found to be a threshold of 440 ms. Furthermore, improvement in 6MWT had considerably less predictive value on mortality and survival than deterioration. Moreover, absolute single-point values outperformed change values for both improvement and worsening.
conclusionOur data confirmed the prognostic relevance of the 6MWT and support the cut-off values stated in most recent guidelines. Furthermore, these results explain why changes in 6MWT did not correlate consistently with prognosis in previous studies.
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Registered trials
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