ArticleParasitology research2018
Mycoplasma hominis impacts gene expression in Trichomonas vaginalis.
Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of the literature on mechanisms of 5-nitroimidazole resistance inParasitology · 2020Pooled it
- Biomolecular Characterization ofBiology · 2025Article
- Effect of essential oils fromFrontiers in parasitology · 2025Article
- Differential Drug Susceptibility across Trichomonasvirus Species Allows for Generation of Varied Isogenic Clones ofPathogens (Basel, Switzerland) · 2024Article
- Review
- Infinity war:Microbial cell (Graz, Austria) · 2023Review
- The Prevalence of Genital Mycoplasmas and Coinfection withMicroorganisms · 2023Article
- Characterisation ofInternational journal of molecular sciences · 2022Article
- Two Different Species ofmBio · 2022Article
- Effect of the Symbiosis withAntibiotics (Basel, Switzerland) · 2022Article
- [Clinical implications of the genus Mycoplasma].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Review
- Recent advances in the molecular biology of the protist parasiteFaculty reviews · 2021Review
- Lack of association between Mycoplasma hominis and Trichomonas vaginalis symbiosis in relation to metronidazole resistance.Parasitology research · 2020Article
- Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis.Parasitology research · 2020Article
- Random transposon insertion in the Mycoplasma hominis minimal genome.Scientific reports · 2019Article
- High Prevalence of Integrative and Conjugative Elements Encoding Transcription Activator-Like Effector Repeats inFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In Europe, up to 90% of isolated Trichomonas vaginalis strains are naturally infected with Mycoplasma hominis, a facultative pathogen of the human genital tract. The consequences of this endosymbiosis are not yet well understood. The aim of the current study was to evaluate the impact of natural and artificial infections with M. hominis on the RNA expression levels of metronidazole susceptibility-associated genes of T. vaginalis. Three T. vaginalis strains (TVSS10-, TVSS25-, G3) without M. hominis, as well as the same strains naturally (TVSS10+, TVSS25+) and artificially (G3-MhSS25, TVSS25-MhSS25) infected with M. hominis, were investigated for their expression profiles of three genes associated with metronidazole resistance (ferredoxin, flavin reductase 1 and pyruvate:ferredoxin oxidoreductase). The minimal inhibitory concentrations (MICs) of metronidazole were evaluated for all combinations and the respective M. hominis-free T. vaginalis strains were used as controls. The sole presence of M. hominis led to a down-regulation of metronidazole susceptibility-associated genes in all T. vaginalis strains tested. Interestingly, the effect was more prominent in the artificial symbioses. Moreover, a twofold enhancement of metronidazole tolerability was observed in three infected T. vaginalis strains, compared to the respective strains without M. hominis. In conclusion, M. hominis had an impact on gene expression in all T. vaginalis strains and on metronidazole MIC in all but one strain tested.
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Registered trials
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