ArticleScientific reports2018
Young and healthy C57BL/6 J mice performing sprint interval training reveal gender- and site-specific changes to the cortical bone.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system.Behavior research methods · 2022Article
- Prolonged treadmill training is not able to prevent ovariectomy-induced bone loss.Frontiers in physiology · 2022Article
- Mouse Fitness as Determined Through Treadmill Running and Walking.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Interval Training Is Not Superior to Endurance Training With Respect to Bone Accrual of Ovariectomized Mice.Frontiers in physiology · 2020Article
- Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice.Frontiers in immunology · 2020Article
- Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice.Journal of visualized experiments : JoVE · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
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Abstract
Physical exercise is considered to impede the bone loss associated with physiological ageing however, a training program that efficiently leads to bone accrual in the healthy does not yet exist. We turned to the C57BL/6 J mouse and designed a sprint interval training for treadmill that was tailored to the individual performance limits. It consisted of four weeks with five training sessions each, followed by another four weeks with three. After completion of the training period, mice were sacrificed and the hind legs were analyzed via µCT and MRI for changes in bone parameters and muscle volume, respectively. Increased performance limits in both sexes confirmed an effect of the treadmill training. However, while male tibiae after eight weeks revealed a significant reduction of cortical bone mass at the distal metaphysis, the cross sectional analysis of female tibiae showed a transient decrease of cortical bone mass after four weeks that was reversed into a significant accrual after eight weeks of training and occurred over the entire length of the tibia. The observed net reduction of female bone mass after four weeks of training is suggestive of a remodelling process which may be delayed in the males.
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