ArticleScientific reports2018
Combined analysis of the salivary microbiome and host defence peptides predicts dental disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Use of the oral microbiota as screening test to identify children at risk for caries development. A systematic review of longitudinal studies.European journal of oral sciences · 2026Pooled it
- Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.Scientific reports · 2021Trial
- A Comparative Analysis of Differences in Salivary hBD-2 Levels and Their Correlation with Dental Caries and Unstimulated Saliva pH in Children with Primary and Permanent Dentition.Diagnostics (Basel, Switzerland) · 2026Article
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Antimicrobial Peptides as Novel Ecological Approaches to Caries Prevention.Drug design, development and therapy · 2026Review
- Key Factors Influencing Caries Development in Preschoolers: A Focus on Socio-Demographic, Maternal Health, and Salivary Biomarkers in 3-Year-Olds.Medical science monitor : international medical journal of experimental and clinical research · 2025Observational
- Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.Frontiers in oral health · 2025Article
- Saliva Decreases Sucrose-Induced Cariogenicity in an Experimental Biological Caries Model.Microorganisms · 2023Article
- Multiomics analysis reveals the genetic and metabolic characteristics associated with the low prevalence of dental caries.Journal of oral microbiology · 2023Article
- Effect of pH-sensitive nanoparticles on inhibiting oral biofilms.Drug delivery · 2022Article
- Association of Candida albicans and CbpScientific reports · 2021Article
- Can Salivary Biomarkers Be Used as Predictors of Dental Caries in Young Adolescents?Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- The salivary microbiota in health and disease.Journal of oral microbiology · 2020Review
- Comparison of the Microbiota and Inorganic Anion Content in the Saliva of Patients with Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-Free Individuals.BioMed research international · 2020Article
- Bacterial biofilm composition in healthy subjects with and without caries experience.Journal of oral microbiology · 2019Article
- Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.Frontiers in cellular and infection microbiology · 2019Article
- Caries-associated oral microbiome in head and neck cancer radiation patients: a longitudinal study.Journal of oral microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the triad of host response, microbiome and disease status is potentially informative for disease prediction, prevention, early intervention and treatment. Using longitudinal assessment of saliva and disease status, we demonstrated that partial least squares modelling of microbial, immunological and clinical measures, grouped children according to future dental disease status. Saliva was collected and dental health assessed in 33 children aged 4 years, and again 1-year later. The composition of the salivary microbiome was assessed and host defence peptides in saliva were quantified. Principal component analysis of the salivary microbiome indicated that children clustered by age and not disease status. Similarly, changes in salivary host defence peptides occurred with age and not in response to, or preceding dental caries. Partial least squares modelling of microbial, immunological and clinical baseline measures clustered children according to future dental disease status. These data demonstrate that isolated evaluation of the salivary microbiome or host response failed to predict dental disease. In contrast, combined assessment of both host response together with the microbiome revealed clusters of health and disease. This type of approach is potentially relevant to myriad diseases that are modified by host-microbiome interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.