ArticleScientific reports2018
Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- A Comprehensive Review on Medium- and Long-Chain Fatty Acid-Derived Metabolites: From Energy Sources to Metabolic Signals.Metabolites · 2026Review
- The a subunit isoforms of V-ATPase are involved in glucose-dependent trafficking of insulin granules.Scientific reports · 2025Article
- Identification of a critical interval for type 2 diabetes QTL on chromosome 4 in DDD-AMammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner.iScience · 2025Article
- A review of research advances in the modulation of olfactory receptors for COPD inflammation and airway remodeling.Frontiers in immunology · 2025Review
- Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.Foods (Basel, Switzerland) · 2024Review
- Review
- Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics.Journal of experimental & clinical cancer research : CR · 2024Article
- Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular-Kidney-Metabolic Axis.Life (Basel, Switzerland) · 2024Review
- Gene expression analysis reveals diabetes-related gene signatures.Human genomics · 2024Article
- Inter-organ communication involved in metabolic regulation at the whole-body level.Inflammation and regeneration · 2023Review
- AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors.International journal of molecular sciences · 2023Article
- Transcriptome Profiling of Anhidrotic Eccrine Sweat Glands Reveals that Olfactory Receptors on Eccrine Sweat Glands Regulate Perspiration in a Ligand-Dependent Manner.JID innovations : skin science from molecules to population health · 2023Article
- Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors.Molecular cancer therapeutics · 2022Article
- Article
- Olfactory disfunction and diabetic complications in type 2 diabetic patients: a pilot study.Endocrine · 2022Article
- Complex Feline Disease Mapping Using a Dense Genotyping Array.Frontiers in veterinary science · 2022Article
- Are Multiple Chemosensory Systems Accountable for COVID-19 Outcome?Journal of clinical medicine · 2021Review
- Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease.Pharmaceutics · 2021Review
- The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-cell line, MIN6. Immunostaining revealed OLFR15 and OLFR821 to be uniformly expressed in pancreatic β-cells. In addition, mRNAs of Olfr15 and Olfr821 were detected in single MIN6 cells. These results indicate that multiple ORs are simultaneously expressed in individual β-cells. Octanoic acid, which is a medium-chain fatty acid contained in food and reportedly interacts with OLFR15, potentiated glucose-stimulated insulin secretion (GSIS), thereby improving glucose tolerance in vivo. GSIS potentiation by octanoic acid was confirmed in isolated pancreatic islets and MIN6 cells and was blocked by OLFR15 knockdown. While Gα
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.