Evidence map›Paper›PMID 29367667›Full record

ArticleScientific reports2018

Quantitative Structure-Activity Relationship Model for HCVNS5B inhibitors based on an Antlion Optimizer-Adaptive Neuro-Fuzzy Inference System.

Mohamed Abd Elaziz, Yasmine S Moemen, Aboul Ella Hassanien, Shengwu Xiong

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohamed Abd ElazizSchool of Computer Science and Technology, Wuhan University of Technology, Wuhan, China. abd_el_aziz_m@yahoo.com.
Yasmine S MoemenClinical Pathology Department, National Liver Institute, Menoufia University, Menofia, Egypt.
Aboul Ella HassanienFaculty of Computers and Information, Cairo University, Giza, Egypt.
Shengwu XiongSchool of Computer Science and Technology, Wuhan University of Technology, Wuhan, China. xiongsw@whut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global prevalence of hepatitis C Virus (HCV) is approximately 3% and one-fifth of all HCV carriers live in the Middle East, where Egypt has the highest global incidence of HCV infection. Quantitative structure-activity relationship (QSAR) models were used in many applications for predicting the potential effects of chemicals on human health and environment. The adaptive neuro-fuzzy inference system (ANFIS) is one of the most popular regression methods for building a nonlinear QSAR model. However, the quality of ANFIS is influenced by the size of the descriptors, so descriptor selection methods have been proposed, although these methods are affected by slow convergence and high time complexity. To avoid these limitations, the antlion optimizer was used to select relevant descriptors, before constructing a nonlinear QSAR model based on the PIC

Indexed as

Quantitative Structure-Activity RelationshipAntiviral AgentsInhibitory Concentration 50Models, StatisticalRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsAntiviral AgentsNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseViral Nonstructural Proteins

Identifiers

PMID29367667
PMCPMC5784174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.