ArticleScientific reports2018
Variations among Streptococcus gallolyticus subsp. gallolyticus strains in connection with colorectal cancer.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Survival and Behavior of Potential Emerging Foodborne PathogenFood science & nutrition · 2026Article
- Systematic analysis of the type VII secretion system inFrontiers in microbiology · 2026Article
- Risk and prognosis of colorectal cancer following bacteraemia withEpidemiology and infection · 2025Article
- Emerging Understanding of Gut Microbiome in Colorectal Cancer and Food-Related Intervention Strategies.Foods (Basel, Switzerland) · 2025Review
- The Oral Microbiome and Cancer.Advances in experimental medicine and biology · 2025Review
- Influence of the gut microbiota on immune cell interactions and cancer treatment.Journal of translational medicine · 2024Review
- Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.ImmunoTargets and therapy · 2024Review
- Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer.Scientific reports · 2023Article
- A pathogenicity locus of Streptococcus gallolyticus subspecies gallolyticus.Scientific reports · 2023Article
- Genetic heterogeneity of colorectal cancer and the microbiome.World journal of gastrointestinal oncology · 2023Review
- Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.PloS one · 2023Article
- Implication of gut microbes and its metabolites in colorectal cancer.Journal of cancer research and clinical oncology · 2023Review
- Article
- Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer.BMC gastroenterology · 2022Article
- First Report on theInternational journal of molecular sciences · 2022Article
- Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer.BMC research notes · 2022Article
- Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation.PLoS pathogens · 2022Article
- Gut microbiota, inflammatory bowel disease and colorectal cancer.World journal of gastroenterology · 2022Review
- Consistent Alterations of Human Fecal Microbes After Transplantation into Germ-free Mice.Genomics, proteomics & bioinformatics · 2022Article
- Review
Corrections and comments
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been reported to display a strong association with colorectal cancer (CRC). It was recently demonstrated to actively promote the development of CRC, underscoring the importance of Sg in both clinical correlation and functional relevance in CRC. Here we investigated several clinical isolates of Sg in their interactions with human colon cancer cells and in mouse models. Some Sg strains were able to stimulate host cell proliferation (proliferation-promoting Sg, PP-Sg) whereas others were not (non-proliferation-promoting Sg, NP-Sg). PP-Sg strains adhered to colon cancer cells much better than NP-Sg strains, suggesting that close contact between Sg and host cells is important. In mice, PP-Sg is significantly better at colonizing the colon tissues of A/J mice compared to NP-Sg, however this difference was not observed in C57BL/6 mice, suggesting that Sg colonization of mouse colon tissues involves specific interactions between bacterial and host factors on the colonic epithelium. Finally, in an azoxymethane-induced mouse model of CRC, PP-Sg promoted tumor development whereas NP-Sg did not. These findings provide clues to the mechanism underlying the Sg-CRC association and have important implications to clinical studies that aim to correlate Sg with clinical and pathological features of CRC.
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