ArticleNature communications2018
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Reservoirs and transmission routes of leprosy; A systematic review.PLoS neglected tropical diseases · 2020Pooled it
- Ancient Mycobacterium leprae genomes reveal a potential origin and dispersal of the ancestral Branch 0.Communications biology · 2026Article
- Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period.Nature communications · 2026Article
- Two pathogens, one disease: Rethinking leprosy diversification through ancient and modern genomes.Clinical and translational medicine · 2026Article
- Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.The Journal of clinical investigation · 2025Article
- Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.Antimicrobial agents and chemotherapy · 2025Article
- Genome wide analyses reveal the role of mutator phenotypes in Mycobacterium tuberculosis drug resistance emergence.npj antimicrobials and resistance · 2025Article
- Unraveling Drug Resistance inInternational journal of microbiology · 2025Review
- Computational investigation of the global prevalence of multidrug resistantJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Genomic and Phenotypic Variations Among Thai-53 andPathogens (Basel, Switzerland) · 2024Article
- Contribution of infectious diseases to the selection of ADH1B and ALDH2 gene variants in Asian populations.Alcohol, clinical & experimental research · 2024Article
- Unlocking Opportunities forACS infectious diseases · 2024Review
- Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches.The Indian journal of medical research · 2024Review
- Fever of unknown origin, blood and cerebrospinal fluid involvement: a leprosy case report.Frontiers in immunology · 2024Article
- Specialized active leprosy search strategies in an endemic area of the Brazilian Amazon identifies a hypermutatedFrontiers in medicine · 2023Article
- Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Hansen's disease (leprosy) in Japan, 1947-2020: an epidemiologic study during the declining phase to elimination.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Pathogenicity and virulence ofVirulence · 2022Review
- Ancient DNA confirmation of lepromatous leprosy in a skeleton with concurrent osteosarcoma, excavated from the leprosarium of St. Mary Magdalen in Winchester, Hants., UK.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- The intracellular pathogenLife science alliance · 2022Article
Corrections and comments
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Authors and funding
43 authors at 18 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae. Although readily curable with multidrug therapy (MDT), over 200,000 new cases are still reported annually. Here, we obtain M. leprae genome sequences from DNA extracted directly from patients' skin biopsies using a customized protocol. Comparative and phylogenetic analysis of 154 genomes from 25 countries provides insight into evolution and antimicrobial resistance, uncovering lineages and phylogeographic trends, with the most ancestral strains linked to the Far East. In addition to known MDT-resistance mutations, we detect other mutations associated with antibiotic resistance, and retrace a potential stepwise emergence of extensive drug resistance in the pre-MDT era. Some of the previously undescribed mutations occur in genes that are apparently subject to positive selection, and two of these (ribD, fadD9) are restricted to drug-resistant strains. Finally, nonsense mutations in the nth excision repair gene are associated with greater sequence diversity and drug resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.