ReviewJournal of cardiovascular development and disease2018
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal.
Review in Journal of cardiovascular development and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Melatonin in Preeclampsia: a Systematic Review of its Role in Pathogenesis and Therapeutic Potential.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- PBMC-derived RNA signatures show impaired ability to regulate immune responses in women developing preeclampsia†.Biology of reproduction · 2026Article
- Evaluation of the Relationship Between Isometric Exercise and Roll-Over Tests and the Levels of Pregnancy-Associated Plasma Protein A and Beta-Human Chorionic Gonadotropin and Neutrophil-Lymphocyte Ratio in the Early Diagnosis of Preeclampsia.Obstetrics and gynecology international · 2026Article
- A Review of Dietary and Lifestyle Management of Pre-Eclampsia and Postpartum Eclampsia.Preventive nutrition and food science · 2025Review
- The incidence and influencing factors of hypertensive disorders during pregnancy in hangzhou, China, between 2012 and 2021.Heliyon · 2025Article
- Knowledge of and perception towards eclampsia among women and men in Unguja Island, Zanzibar: A qualitative study.PloS one · 2025Article
- The correlation between hemoglobin concentration and blood pressure during pregnancy in different trimesters.BMC pregnancy and childbirth · 2024Article
- Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia.Current issues in molecular biology · 2024Review
- An association of deficiencies in balanced dietary practices and inadequate iron and folic acid supplement's intake during pregnancy and increasing risk of pre-eclampsia or eclampsia among Indian women.PLOS global public health · 2024Article
- Posterior reversible encephalopathy syndrome in postpartum patients with gestational hypertension: A case report emphasizing early recognition and management.Radiology case reports · 2023Article
- Association between endothelial nitric oxide synthase (eNOS) gene variants and nitric oxide production in preeclampsia: a case-control study in Ghana.Scientific reports · 2023Article
- Perceived Cardiovascular Disease Risk Following Preeclampsia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Implementation of maternal guidelines for gravid teenagers with hypertensive disorders in KwaZulu-Natal.Curationis · 2023Article
- Labetalol and soluble endoglin aggravate bile acid retention in mice with ethinylestradiol-induced cholestasis.Frontiers in pharmacology · 2023Article
- Histopathological, ultrastructural, and immunohistochemical examination of changes in the placenta as a result of severe preeclampsia.Acta cirurgica brasileira · 2023Article
- The effect of thromboembolic prophylaxis after cesarean section in patients with hypertensive disorders.Northern clinics of Istanbul · 2023Article
- Postpartum Assessment of the Correlation between Serum Hormone Levels of Estradiol, Progesterone, Prolactin and ß-HCG and Blood Pressure Measurements in Pre-Eclampsia Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers.Journal of assisted reproduction and genetics · 2022Article
- Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells.Bioengineered · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-eclampsia and eclampsia are two hypertensive disorders of pregnancy, considered major causes of maternal and perinatal death worldwide. Pre-eclampsia is a multisystemic disease characterized by the development of hypertension after 20 weeks of gestation, with the presence of proteinuria or, in its absence, of signs or symptoms indicative of target organ injury. Eclampsia represents the consequence of brain injuries caused by pre-eclampsia. The correct diagnosis and classification of the disease are essential, since the therapies for the mild and severe forms of pre-eclampsia are different. Thus, this review aims to describe the most advisable antepartum pharmacotherapy for pre-eclampsia and eclampsia applied in Portugal and based on several national and international available guidelines. Slow-release nifedipine is the most recommended drug for mild pre-eclampsia, and labetalol is the drug of choice for the severe form of the disease. Magnesium sulfate is used to prevent seizures caused by eclampsia. Corticosteroids are used for fetal lung maturation. Overall, the pharmacological prevention of these diseases is limited to low-dose aspirin, so it is important to establish the safest and most effective available treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.