ReviewJournal of cardiovascular development and disease2017
Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us?
Review in Journal of cardiovascular development and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Molecular characterization of FAM222B as a novel disease gene for dominant cardiovascular laterality defects.Scientific reports · 2026Article
- Article
- Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry.Nature communications · 2024Article
- Molecular analysis of a self-organizing signaling pathway forProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Morphoelastic models discriminate between different mechanisms of left-right asymmetric stomach morphogenesis.Cells & development · 2024Article
- Emerging principles of primary cilia dynamics in controlling tissue organization and function.The EMBO journal · 2023Review
- Dand5 is involved in zebrafish tailbud cell movement.Frontiers in cell and developmental biology · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- The twists and turns of left-right asymmetric gut morphogenesis.Development (Cambridge, England) · 2020Review
- Simulations of particle tracking in the oligociliated mouse node and implications for left-right symmetry-breaking mechanics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Randomization of Left-right Asymmetry and Congenital Heart Defects: The Role ofCirculation. Genomic and precision medicine · 2019Article
- Special Issue: Left-Right Asymmetry and Cardiac Morphogenesis.Journal of cardiovascular development and disease · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm of the neurula stage embryo, which results from a cilia-driven leftward flow of extracellular fluids at the left-right organizer. This scenario is widely accepted for laterality determination in wildtype specimens. Deviations from this norm come in different flavors. At the level of organ morphogenesis, laterality may be inverted (situs inversus) or non-concordant with respect to the main body axis (situs ambiguus or heterotaxia). At the level of Nodal cascade gene activation, expression may be inverted, bilaterally induced, or absent. In a given genetic situation, patterns may be randomized or predominantly lacking laterality (absence or bilateral activation). We propose that the distributions of patterns observed may be indicative of the underlying molecular defects, with randomizations being primarily caused by defects in the flow-generating ciliary set-up, and symmetrical patterns being the result of impaired flow sensing, on the left, the right, or both sides. This prediction, the reasoning of which is detailed in this review, pinpoints functions of genes whose role in laterality determination have remained obscure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.