ReviewJournal of cardiovascular development and disease2016
Genetic and Epigenetic Mechanisms Linking Air Pollution and Congenital Heart Disease.
Review in Journal of cardiovascular development and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis.International journal of environmental research and public health · 2018Pooled it
- Maternal Exposure to Air Pollution During Early Pregnancy and Congenital Heart Disease: An Exploratory Case-Control Analysis from Delhi NCR.Indian journal of pediatrics · 2026Article
- Maternal exposure to ambient air pollution and risk of congenital limb defects in offspring.Scientific reports · 2026Article
- Increased methylation levels of theEpigenomics · 2025Article
- Paternal peri-conceptional physical activity and the risk of congenital heart disease in offspring: A case-control study.Andrology · 2025Observational
- Cardiomyocyte proliferation and regeneration in congenital heart disease.Pediatric discovery · 2024Article
- Prenatal exposure to air pollutants and the risk of congenital heart disease: a Korean national health insurance database-based study.Scientific reports · 2024Article
- Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study.World journal of pediatrics : WJP · 2024Article
- Environmental Signals.Advances in experimental medicine and biology · 2024Article
- Invited Perspective: Air Pollution and Congenital Heart Defects (CHDs)-a Summary of Two Decades and Future Direction in Research.Environmental health perspectives · 2023Article
- Ambient air pollutants in the first trimester of pregnancy and birth defects: an observational study.BMJ open · 2023Observational
- Early prenatal exposure to air pollutants and congenital heart disease: a nested case-control study.Environmental health and preventive medicine · 2023Article
- Epigenetics and Congenital Heart Diseases.Journal of cardiovascular development and disease · 2022Review
- Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk.International journal of environmental research and public health · 2021Review
- Gene-environment interactions between air pollution and biotransformation enzymes and risk of birth defects.Birth defects research · 2021Article
- The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?International journal of molecular sciences · 2020Review
- Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.American journal of medical genetics. Part A · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies strongly suggest that parental air pollutants exposure during the periconceptional period may play a major role in causing fetal/newborn malformations, including a frequent heterogeneity in the methods applied and a difficulty in estimating the clear effect of environmental toxicants. Moreover, only some couples exposed to toxicants during the pre-conception period give birth to a child with congenital anomalies. The reasons for such phenomena remain elusive but they can be explained by the individual, innate ability to metabolize these contaminants that eventually defines the ultimate dose of a biological active toxicant. In this paper, we reviewed the major evidence regarding the role of parental air pollutant exposure on congenital heart disease (CHD) risk as well as the modulating effect on detoxification systems. Finally, major epigenetic alterations induced by adverse environment contaminants have been revised as possible mechanisms altering a correct heart morphogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.