Evidence map›Paper›PMID 29367561›Full record

ReviewJournal of cardiovascular development and disease2016

Probing the Electrophysiology of the Developing Heart.

Michiko Watanabe, Andrew M Rollins, Luis Polo-Parada, Pei Ma, Shi Gu, Michael W Jenkins

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. TheFrontiers in physiology · 2023
    Article
  3. Article
  4. Engineering Heart Morphogenesis.Trends in biotechnology · 2020
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michiko WatanabeDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. mxw13@case.edu.
Andrew M RollinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. rollins@case.edu.
Luis Polo-ParadaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65201, USA. poloparadal@missouri.edu.ORCID 0000-0002-5221-6060
Pei MaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. pxm261@case.edu.
Shi GuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. shi.gu@case.edu.ORCID 0000-0001-5469-0375
Michael W JenkinsDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. mwj5@case.edu.

Funding

Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart DefectsR01HL126747 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2015 to 2025
$6.4M
OCT Imaging Technology for Developmental Cardiology ResearchR01HL083048 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN · 2006 to 2016
$3.2M
Optical pacing of the embryonic heartR21HL115373 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2012 to 2013
$422k
NHLBI NIH HHS R01 HL083048NHLBI NIH HHS R01 HL126747NHLBI NIH HHS R21 HL115373
6 · The paper itself

Abstract

Many diseases that result in dysfunction and dysmorphology of the heart originate in the embryo. However, the embryonic heart presents a challenging subject for study: especially challenging is its electrophysiology. Electrophysiological maturation of the embryonic heart without disturbing its physiological function requires the creation and deployment of novel technologies along with the use of classical techniques on a range of animal models. Each tool has its strengths and limitations and has contributed to making key discoveries to expand our understanding of cardiac development. Further progress in understanding the mechanisms that regulate the normal and abnormal development of the electrophysiology of the heart requires integration of this functional information with the more extensively elucidated structural and molecular changes.

Indexed as

atrioventricular junctionatrioventricular nodecardiac conduction systemcardiovascular developmentelectrodeselectrophysiologyHis-Purkinje systemoptical mappingoptical pacingsinoatrial node

Identifiers

PMID29367561
PMCPMC5715694

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.