ArticleJournal of cardiovascular development and disease2017
Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury.
Article in Journal of cardiovascular development and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- MiR-145-5p modulates collagen production and fibroblast behaviour after cardiac injury partially via COL5A1.Basic research in cardiology · 2026Article
- Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish.Nature cardiovascular research · 2026Article
- Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration.Nature communications · 2025Article
- Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish.Nature communications · 2024Article
- Distinct features of the regenerating heart uncovered through comparative single-cell profiling.Biology open · 2024Article
- Distinct features of the regenerating heart uncovered through comparative single-cell profiling.bioRxiv : the preprint server for biology · 2023Article
- Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration.Protein & cell · 2023Article
- Regeneration of the heart: from molecular mechanisms to clinical therapeutics.Military Medical Research · 2023Review
- The regenerative response of cardiac interstitial cells.Journal of molecular cell biology · 2023Article
- Hooked on heart regeneration: the zebrafish guide to recovery.Cardiovascular research · 2022Review
- Interacting Effects of Sea Louse (Frontiers in immunology · 2022Article
- Regulation of collagen deposition in the trout heart during thermal acclimation.Current research in physiology · 2022Article
- Cardiac regenerative capacity: an evolutionary afterthought?Cellular and molecular life sciences : CMLS · 2021Review
- The Zebrafish Cardiac Endothelial Cell-Roles in Development and Regeneration.Journal of cardiovascular development and disease · 2021Review
- Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Review
- Zebrafish as a Smart Model to Understand Regeneration After Heart Injury: How Fish Could Help Humans.Frontiers in cardiovascular medicine · 2019Review
- Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration.Scientific reports · 2018Article
- Zebrafish heart regeneration: 15 years of discoveries.Regeneration (Oxford, England) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Myocardial infarction is the major cause of cardiac injury in western countries and can result in a massive loss of heart cells, leading eventually to heart failure. A fibrotic collagen-rich scar may prevent ventricular wall rupture, but also may result in heart failure because of its stiffness. In zebrafish, cardiac cryoinjury triggers a fibrotic response and scarring. Unlike with mammals, zebrafish heart has the striking ability to regenerate and to resolve the scar. Thus, understanding the mechanisms of scar resolution in zebrafish heart might facilitate the design of new therapeutic approaches to improve the recovery of patients. To visualize the collagenolytic activity within the zebrafish heart following cryoinjury, we used an in situ collagen zymography assay. We detected expression of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.