Observational studyJournal of the American Heart Association2018
Reduced Long-Term Risk of Aortic Aneurysm and Aortic Dissection Among Individuals With Type 2 Diabetes Mellitus: A Nationwide Observational Study.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Tobacco smoking and the risk of aortic dissection in the UK Biobank and a meta-analysis of prospective studies.Scientific reports · 2025Pooled it
- The effect of exercise training intervention for patients with abdominal aortic aneurysm on cardiovascular and cardiorespiratory variables: an updated meta-analysis of randomized controlled trials.BMC cardiovascular disorders · 2024Pooled it
- Management of Spontaneous Isolated Mesenteric Artery Dissection: A Systematic Review.Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · 2021Pooled it
- Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies.European journal of epidemiology · 2019Pooled it
- Adiposity and the risk of aortic dissection incidence and mortality: results from the UK Biobank, the J-SHC study and a meta-analysis of cohort studies.European journal of epidemiology · 2026Article
- Incidence and risk factors for aortic dissection in a community-based cohorts: The Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) studies.American journal of preventive cardiology · 2026Article
- Association of 3-Day Postoperative Blood Glucose Variability With All-Cause Mortality in ICU Patients After Surgical Repair of Acute Type A Aortic Dissection: A Retrospective Cohort Study Using the MIMIC-IV Database.Clinical cardiology · 2026Article
- Fate of dilated ascending aorta after transcatheter aortic valve replacement.JTCVS structural and endovascular · 2025Article
- Blood pressure, hypertension, and the risk of aortic aneurysm in the UK Biobank.BMC cardiovascular disorders · 2025Article
- Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Reduced Incidence of Aortic Dissection in Patients With Type 2 Diabetes Treated With Sodium Glucose Transporter 2 Inhibitors.Journal of the American Heart Association · 2025Article
- Potential Protective Role of Diabetes Mellitus on Aortic Aneurysms.Aorta (Stamford, Conn.) · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Diabetes does not increase in-hospital or short-term mortality in patients undergoing surgical repair for type A aortic dissection: insight from the national readmission database.Cardiovascular diabetology · 2024Article
- Mendelian randomization did not support the causal effect of diabetes on aortic diseases.Internal and emergency medicine · 2024Article
- Diabetes is not a negative prognostic factor for 30-days mortality after surgery for acute type A aortic dissection.Cardiovascular endocrinology & metabolism · 2024Article
- Non-coronary peripheral arterial complications in people with type 2 diabetes: a Swedish retrospective cohort study.The Lancet regional health. Europe · 2024Article
- Non-coronary arterial outcomes in people with type 1 diabetes mellitus: a Swedish retrospective cohort study.The Lancet regional health. Europe · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo studies have examined long-term risks for aortic aneurysm (AA) and aortic dissection (AD) or mortality after AA or AD hospitalization among patients with type 2 diabetes mellitus (T2DM). METHODS AND
resultsIn this observational cohort study, we linked data for patients with T2DM in the Swedish National Diabetes Register, and 5 individually matched population-based control subjects (CSs) without diabetes mellitus (on the basis of sex, age, and county), to other national databases to capture hospitalizations and death. We examined the risk of hospitalization for AA and AD, as well as mortality risk after AA and AD using Kaplan-Meier curves and Cox regression hazards models. Data on 448 319 patients with T2DM and 2 251 015 CSs were obtained between 1998 and 2015. Mean follow-up time was 7.0 years for the T2DM group and 7.2 years for the CS group. Patients with T2DM had a relative risk reduction of 28% (hazard ratio, 0.72; 95% confidence interval, 0.68-0.76;
conclusionsPatients with T2DM had significantly reduced risks of AA and AD as well as reduced risk of mortality after hospitalization for AA, compared to CS. Data suggest that glycated cross-links in aortic tissue may play a protective role in the progression of aortic diseases among patients with T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.