ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Cortical Neural Activity Predicts Sensory Acuity Under Optogenetic Manipulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus.PLoS biology · 2026Article
- Distinct Inhibitory Neurons Differently Shape Neuronal Codes for Sound Intensity in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional diversities within neurons and astrocytes in the adult rat auditory cortex revealed by single-nucleus RNA sequencing.Scientific reports · 2024Article
- Dynamics of cortical contrast adaptation predict perception of signals in noise.Nature communications · 2023Article
- Parvalbumin neurons enhance temporal coding and reduce cortical noise in complex auditory scenes.Communications biology · 2023Article
- Do sparse brain activity patterns underlie human cognition?NeuroImage · 2022Article
- Neuronal activity in sensory cortex predicts the specificity of learning in mice.Nature communications · 2022Article
- Neural Correlates of Learning Pure Tones or Natural Sounds in the Auditory Cortex.Frontiers in neural circuits · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Excitatory and inhibitory neurons in the mammalian sensory cortex form interconnected circuits that control cortical stimulus selectivity and sensory acuity. Theoretical studies have predicted that suppression of inhibition in such excitatory-inhibitory networks can lead to either an increase or, paradoxically, a decrease in excitatory neuronal firing, with consequent effects on stimulus selectivity. We tested whether modulation of inhibition or excitation in the auditory cortex of male mice could evoke such a variety of effects in tone-evoked responses and in behavioral frequency discrimination acuity. We found that, indeed, the effects of optogenetic manipulation on stimulus selectivity and behavior varied in both magnitude and sign across subjects, possibly reflecting differences in circuitry or expression of optogenetic factors. Changes in neural population responses consistently predicted behavioral changes for individuals separately, including improvement and impairment in acuity. This correlation between cortical and behavioral change demonstrates that, despite the complex and varied effects that these manipulations can have on neuronal dynamics, the resulting changes in cortical activity account for accompanying changes in behavioral acuity.
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