ArticleProceedings. Biological sciences2018
Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Exploring emotional expression in invertebrates: mechanisms, functions and phylogeny.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera).Nature communications · 2025Article
- Do honey phytochemicals modulate forager aggression and the gut microbiome in the honey bee (Apis mellifera L.)?Biology open · 2025Article
- Integrated Transcriptomic and Metabolomic Insights into "I See You" (ISY) Defensive Behavior inInsects · 2025Article
- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
- Article
- Physiological specialization of the brain in bumble bee castes: Roles of dopamine in mating-related behaviors in female bumble bees.PloS one · 2024Article
- Single-cell dissection of aggression in honeybee colonies.Nature ecology & evolution · 2023Article
- Article
- Granger Causality Analysis of Transient Calcium Dynamics in the Honey Bee Antennal Lobe Network.Insects · 2023Article
- Review
- Geosmin suppresses defensive behaviour and elicits unusual neural responses in honey bees.Scientific reports · 2023Article
- Extracting individual characteristics from population data reveals a negative social effect during honeybee defence.PLoS computational biology · 2022Article
- Review
- The short neuropeptide F (sNPF) promotes the formation of appetitive visual memories in honey bees.Biology letters · 2022Article
- The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect.iScience · 2022Article
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Altering social cue perception impacts honey bee aggression with minimal impacts on aggression-related brain gene expression.Scientific reports · 2019Article
- Foraging Experiences Durably Modulate Honey Bees' Sucrose Responsiveness and Antennal Lobe Biogenic Amine Levels.Scientific reports · 2019Article
- Increased aggression and reduced aversive learning in honey bees exposed to extremely low frequency electromagnetic fields.PloS one · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The defence of a society often requires that some specialized members coordinate to repel a threat at personal risk. This is especially true for honey bee guards, which defend the hive and may sacrifice their lives upon stinging. Central to this cooperative defensive response is the sting alarm pheromone, which has isoamyl acetate (IAA) as its main component. Although this defensive behaviour has been well described, the neural mechanisms triggered by IAA to coordinate stinging have long remained unknown. Here we show that IAA upregulates brain levels of serotonin and dopamine, thereby increasing the likelihood of an individual bee to attack and sting. Pharmacological enhancement of the levels of both amines induces higher defensive responsiveness, while decreasing them via antagonists decreases stinging. Our results thus uncover the neural mechanism by which an alarm pheromone recruits individuals to attack and repel a threat, and suggest that the alarm pheromone of honey bees acts on their response threshold rather than as a direct trigger.
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