Evidence map›Paper›PMID 29367353›Full record

ArticleThe Journal of cell biology2018

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions.

Dijin Xu, Yuqi Li, Lizhen Wu, Ying Li, Dongyu Zhao, Jinhai Yu, Tuozhi Huang, Charles Ferguson, Robert G Parton, Hongyuan Yang and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 237 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Heterogeneity, dynamics and organelle interactions of lipid droplets.Nature reviews. Molecular cell biology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. GDI2 protein: research progress and its mechanisms in diseases.Frontiers in cell and developmental biology · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Impact of protein prenylation inhibition onJournal of bacteriology · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  20. Essential Biology of Lipid Droplets.Annual review of biochemistry · 2025
    Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dijin XuState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0001-7955-4855
Yuqi LiState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Lizhen WuState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0002-7832-465X
Ying LiState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0003-4080-3214
Dongyu ZhaoState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Jinhai YuState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Tuozhi HuangState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Charles FergusonInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Robert G PartonInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia.ORCID 0000-0002-7494-5248
Hongyuan YangSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0000-0002-8482-6031
Peng LiState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China li-peng@mail.tsinghua.edu.cn.ORCID 0000-0002-8629-5246
Center for Life Sciences · CNThe University of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid incorporation from endoplasmic reticulum (ER) to lipid droplet (LD) is important in controlling LD growth and intracellular lipid homeostasis. However, the molecular link mediating ER and LD cross talk remains elusive. Here, we identified Rab18 as an important Rab guanosine triphosphatase in controlling LD growth and maturation.

Indexed as

3T3-L1 CellsAnimalsEndoplasmic ReticulumLipid DropletsMicerab GTP-Binding ProteinsSNARE ProteinsRab18 protein, mouserab GTP-Binding ProteinsSNARE Proteins

Identifiers

PMID29367353
PMCPMC5839781
OpenAlexW2785234547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.