ArticleScience translational medicine2018
Integrin α
Abstract read
In one paragraph
Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 95 citations in OpenAlex.
- Injectable Contraceptives Differentially Affect Select CD4+ HIV-1 Target Cells in the Genital Tract but Not Systemically: Implications for HIV-1 Acquisition.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Trial
- Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size.JCI insight · 2024Trial
- Pre-infection plasma cytokines and chemokines as predictors of HIV disease progression.Scientific reports · 2022Trial
- Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways.Nature communications · 2019Trial
- Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation.The Journal of clinical investigation · 2019Trial
- Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.Science translational medicine · 2018Trial
- The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression.PLoS pathogens · 2026Article
- Linking gut microbiome to HIV-1 reservoir size in people living with HIV.Gut pathogens · 2026Article
- IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells.PLoS pathogens · 2026Article
- Article
- NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1.The Journal of clinical investigation · 2025Article
- Integrin α4β7 as a predictor of HIV acquisition: one thread in a complex tapestry.The Journal of clinical investigation · 2025Article
- Mucosal immunity in acute HIV: a review of recent work.Current opinion in HIV and AIDS · 2025Review
- Pre-Human Immunodeficiency Virus (HIV) α4β7hi CD4+ T Cells and HIV Risk Among Heterosexual Individuals in Africa.The Journal of infectious diseases · 2025Article
- IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques.JCI insight · 2025Article
- Gut microbiome as a potential mediator linking sexual behaviors to immune profiles in HIV-negative men who have sex with men: a multi-omics study.Frontiers in immunology · 2025Article
- Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine.Frontiers in immunology · 2025Article
- Increases in the susceptibility of human endometrial CD4Frontiers in immunology · 2024Article
- The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7.PLoS pathogens · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 11 institutions in 7 countries.
Aida SivroCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0001-9215-5285
Alexandra SchuetzDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.ORCID 0000-0003-2829-1340
Daniel ShewardDivision of Medical Virology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service, Cape Town 7925, South Africa.
Vineet JoagDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Sergey YegorovDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.ORCID 0000-0002-7136-7921
Lenine J LiebenbergCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0001-6768-8776
Nonhlanhla Yende-ZumaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
Andrew StalkerDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.ORCID 0000-0002-0690-644X
Ruth S MwatelahDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.ORCID 0000-0001-5761-1169
Philippe SelhorstDivision of Medical Virology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service, Cape Town 7925, South Africa.
Nigel GarrettCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0002-4530-234X
Natasha SamsunderCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
Anisha BalgobinCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
Fatima NawazLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.
Claudia CicalaLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.
James ArthosLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.
Anthony S FauciLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.
Aggrey Omu AnzalaKenyan AIDS Vaccine Initiative, Nairobi 00202, Kenya.
Joshua KimaniDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.ORCID 0000-0003-2858-5007
Bernard S BagayaUganda Virus Research Institute-International AIDS Vaccine Initiative HIV Vaccine Program, Plot 51-59, Nakiwogo Road, Entebbe, Uganda.ORCID 0000-0002-3847-2615
Noah KiwanukaUganda Virus Research Institute-International AIDS Vaccine Initiative HIV Vaccine Program, Plot 51-59, Nakiwogo Road, Entebbe, Uganda.
Carolyn WilliamsonCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0003-0125-1226
Rupert KaulDepartment of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.ORCID 0000-0002-1586-4093
Jo-Ann S PassmoreCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0002-1471-4245
Nittaya PhanuphakSouth East Asia Research Collaboration in HIV (SEARCH), The Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.ORCID 0000-0002-0036-3165
Jintanat AnanworanichU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute, Silver Spring, MD 20817, USA.ORCID 0000-0003-1369-3224
Aftab AnsariDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-4607-7268
Quarraisha Abdool KarimCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0002-0985-477X
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0002-4986-2133
Lyle R McKinnonCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.ORCID 0000-0002-7157-0700
CAPRISA004 and RV254 study groups
Centre for the AIDS Programme of Research in South Africa · ZANational Health Laboratory Service · ZANational Institute of Allergy and Infectious Diseases · USUniversity of Nairobi · KEHenry M. Jackson Foundation · USInternational AIDS Vaccine Initiative · USUniversity of Manitoba · CAUniversity of Toronto · CAEmory University · USThai Red Cross Society · THUniversity Health Network · CA
Funding
Role of HIV Envelope Proteins In Viral Replication and HIV PathogenesisZIAAI000887 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CICALA, CLAUDIA · 2009 to 2025
$15.2MInteraction of HIV envelope with cell surface receptorsZIAAI000883 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ARTHOS, JAMES L · 2009 to 2024
$14.0MIntegrin a4b7 as a predictor of HIV acquisition and pathogenesisR21AI115978 · NIAID · CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA · PI ANSARI, AFTAB A., MCKINNON, LYLE · 2015 to 2016
$333kNIAID NIH HHS R21 AI115978
Abstract
The gastrointestinal (GI) mucosa is central to HIV pathogenesis, and the integrin α
Indexed as
Disease ProgressionAdultAntiretroviral Therapy, Highly ActiveCD4-Positive T-Lymphocytesenv Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHumansIntegrinsIntestinal MucosaLogistic ModelsMultivariate AnalysisProportional Hazards ModelsYoung Adultenv Gene Products, Human Immunodeficiency Virusintegrin alpha4beta7Integrins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.