ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
How Forces Fold the Cerebral Cortex.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles.Developmental neurobiology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Gyral Crowns Contribute to the Cortical Infrastructure of Human Face Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Burst of gyrification in the human brain after birth.Communications biology · 2025Article
- Characterization of the Porcine Cingulate Sulcus Cytoarchitecture.The Journal of comparative neurology · 2025Article
- Article
- Quantifying the Timing of Gyral and Sulcal Formation Relative to Growth in the Ferret Cerebral Cortex.Developmental neuroscience · 2025Article
- The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Article
- Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population.Molecular autism · 2024Article
- Using multivariate pattern analysis to increase effect sizes for event-related potential analyses.Psychophysiology · 2024Article
- Design of neural organoids engineered by mechanical forces.IBRO neuroscience reports · 2024Review
- Longitudinal MRI of the developing ferret brain reveals regional variations in timing and rate of growth.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Improved understanding of the factors that govern folding of the cerebral cortex is desirable for many reasons. The existence of consistent patterns in folding within and between species suggests a fundamental role in brain function. Abnormal folding patterns found in individuals affected by a diverse array of neurodevelopmental disorders underline the clinical relevance of understanding the folding process. Recent experimental and computational efforts to elucidate the biomechanical forces involved in cerebral cortical folding have converged on a consistent approach. Brain growth is modeled with two components: an expanding outer zone, destined to become the cerebral cortex, is mechanically coupled to an inner zone, destined to become white matter, that grows at a slower rate, perhaps in response to stress induced by expansion from the outer layer. This framework is consistent with experimentally observed internal forces in developing brains, and with observations of the folding process in physical models. In addition, computational simulations based on this foundation can produce folding patterns that recapitulate the characteristics of folding patterns found in gyroencephalic brains. This perspective establishes the importance of mechanical forces in our current understanding of how brains fold, and identifies realistic ranges for specific parameters in biophysical models of developing brain tissue. However, further refinement of this approach is needed. An understanding of mechanical forces that arise during brain development and their cellular-level origins is necessary to interpret the consequences of abnormal brain folding and its role in functional deficits as well as neurodevelopmental disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.