Evidence map›Paper›PMID 29367251›Full record

ArticleJournal of virology2018

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain.

E Kip, J Staal, L Verstrepen, H G Tima, S Terryn, M Romano, K Lemeire, V Suin, A Hamouda, M Kalai and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. The CARD14Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Frontiers in microbiology · 2023
    Article
  5. Article
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  7. IdentifyingJournal of immunology research · 2022
    Article
  8. Article
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  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

E KipNational Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
J StaalCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.
L VerstrepenCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.
H G TimaScientific Service Immunology, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
S TerrynNational Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
M RomanoScientific Service Immunology, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
K LemeireCenter for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.
V SuinNational Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
A HamoudaNational Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
M KalaiNational Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.
R Beyaert *Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium rudi.beyaert@irc.vib-ugent.be steven.vangucht@wiv-isp.be.
S Van Gucht *National Reference Center of Rabies, Viral Diseases, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium rudi.beyaert@irc.vib-ugent.be steven.vangucht@wiv-isp.be.ORCID https://orcid.org/0000-0002-8150-9372
Ghent University · BEInstitut Scientifique de Santé Publique · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MALT1 is involved in the activation of immune responses, as well as in the proliferation and survival of certain cancer cells. MALT1 acts as a scaffold protein for NF-κB signaling and a cysteine protease that cleaves substrates, further promoting the expression of immunoregulatory genes. Deregulated MALT1 activity has been associated with autoimmunity and cancer, implicating MALT1 as a new therapeutic target. Although MALT1 deficiency has been shown to protect against experimental autoimmune encephalomyelitis, nothing is known about the impact of MALT1 on virus infection in the central nervous system. Here, we studied infection with an attenuated rabies virus, Evelyn-Rotnycki-Abelseth (ERA) virus, and observed increased susceptibility with ERA virus in MALT1

Indexed as

Lymphocyte ActivationAnimalsBrainInflammationMiceMice, KnockoutMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinRabiesRabies virusT-LymphocytesMalt1 protein, mouseMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinERAimmunityMALT1neuroinflammationrabies virus

Identifiers

PMID29367251
PMCPMC5874405
OpenAlexW2784708236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.