Evidence map›Paper›PMID 29367236›Full record

ArticleJournal of the Royal Society, Interface2018

Stresses and strains on the human fetal skeleton during development.

Stefaan W Verbruggen, Bernhard Kainz, Susan C Shelmerdine, Joseph V Hajnal, Mary A Rutherford, Owen J Arthurs, Andrew T M Phillips, Niamh C Nowlan

Open access · hybridAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Computation of Fetal Kicking in Various Fetal Health Examinations: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  3. Trial
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  9. Trabecular Bone Ontogeny of the Human Distal Tibia.American journal of biological anthropology · 2025
    Article
  10. Review
  11. A nonsenseHeliyon · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  16. Article
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  19. Review
  20. Endostructural and periosteal growth of the human humerus.Anatomical record (Hoboken, N.J. : 2007) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stefaan W VerbruggenDepartment of Bioengineering, Imperial College London, London, UK.ORCID 0000-0002-2321-1367
Bernhard KainzDepartment of Computing, Imperial College London, London, UK.ORCID 0000-0002-7813-5023
Susan C ShelmerdineDepartment of Radiology, Great Ormond Street Hospital, London, UK.
Joseph V HajnalDepartment of Biomedical Engineering & Centre for the Developing Brain, School of Biomedical Engineering and Imaging Science, Kings College London, London, UK.
Mary A RutherfordDepartment of Perinatal Imaging and Health & Centre for the Developing Brain, School of Biomedical Engineering and Imaging Science, Kings College London, London, UK.
Owen J ArthursUCL Great Ormond Street Institute of Child Health, London, UK.
Andrew T M PhillipsDepartment of Civil and Environmental Engineering, Imperial College London, London, UK.
Niamh C NowlanDepartment of Bioengineering, Imperial College London, London, UK n.nowlan@imperial.ac.uk.ORCID 0000-0002-9083-6279
Imperial College London · GBGreat Ormond Street Hospital · GBKing's College London · GB

Funding

Department of Health CDF-2017-10-037Department of Health NIHR-CS-012-002European Research Council 319456Medical Research Council MC_U120088465Medical Research Council MR/R002118/1Versus Arthritis 20683
6 · The paper itself

Abstract

Mechanical forces generated by fetal kicks and movements result in stimulation of the fetal skeleton in the form of stress and strain. This stimulation is known to be critical for prenatal musculoskeletal development; indeed, abnormal or absent movements have been implicated in multiple congenital disorders. However, the mechanical stress and strain experienced by the developing human skeleton

Indexed as

FetusSkeletonFemaleFetal DevelopmentHumansMaleMusculoskeletal DevelopmentStress, Physiologicalbiomechanical stimulicine-MRIfinite element analysisjoint biomechanicsmusculo-skeletal development

Identifiers

PMID29367236
PMCPMC5805961
OpenAlexW2785199373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.