ArticleJournal of molecular biology2018
Mechanism of Inhibition of Translation Termination by Blasticidin S.
Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Halting translation by the letter with sequence-selective small molecules.Nature chemical biology · 2026Review
- Structure-Guided Semisynthesis of Blasticidin S-Amicetin Chimeras as Selective Ribosome Inhibitors.Journal of the American Chemical Society · 2026Article
- Anti-Magnaporthe oryzae Activity of Streptomyces bikiniensis HD-087 In Vitro and Bioinformatics Analysis of Polyketide Synthase Gene pksL.Current microbiology · 2024Article
- Forgotten Natural Products: Semisynthetic Development of Blasticidin S As an Antibiotic Lead.ACS medicinal chemistry letters · 2024Article
- Antifungal Activity and Mechanism of Xenocoumacin 1, a Natural Product fromJournal of fungi (Basel, Switzerland) · 2024Article
- An easy tool to monitor the elemental steps of in vitro translation via gel electrophoresis of fluorescently labeled small peptides.RNA (New York, N.Y.) · 2024Article
- Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs.Nature chemical biology · 2023Article
- Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome.Nature communications · 2023Article
- Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity.RSC medicinal chemistry · 2023Article
- Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.Natural product reports · 2021Review
- Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.Nucleic acids research · 2021Article
- ArfB can displace mRNA to rescue stalled ribosomes.Nature communications · 2020Article
- CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.Biomolecules · 2020Article
- Article
- Mechanism of premature translation termination on a sense codon.The Journal of biological chemistry · 2018Article
- Conformational Control of Translation Termination on the 70S Ribosome.Structure (London, England : 1993) · 2018Article
- GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the mechanisms of inhibitors of translation termination may inform development of new antibacterials and therapeutics for premature termination diseases. We report the crystal structure of the potent termination inhibitor blasticidin S bound to the ribosomal 70S•release factor 1 (RF1) termination complex. Blasticidin S shifts the catalytic domain 3 of RF1 and restructures the peptidyl transferase center. Universally conserved uridine 2585 in the peptidyl transferase center occludes the catalytic backbone of the GGQ motif of RF1, explaining the structural mechanism of inhibition. Rearrangement of domain 3 relative to the codon-recognition domain 2 provides insight into the dynamics of RF1 implicated in termination accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.