Evidence map›Paper›PMID 29365318›Full record

ArticleBlood advances2018

Recipient priming to one RBC alloantigen directly enhances subsequent alloimmunization in mice.

Seema R Patel, Ashley Bennett, Kathryn Girard-Pierce, Cheryl L Maier, Satheesh Chonat, Connie M Arthur, Patricia E Zerra, Amanda Mener, Sean R Stowell

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Analysis of Galectin Binding to Blood Group Expressing Bacteria.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Use of Microbial Microarrays to Define Antibody Specificity.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Analysis of Erythrocyte Membrane Alloantigens.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Acute Incompatible Red Blood Cell Transfusion in Mice.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Article
  8. Article
  9. Research progress in RBC alloimmunization.Frontiers in immunology · 2025
    Review
  10. Review
  11. Article
  12. Tropical medicine and infectious disease · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Evaluation of the Bactericidal Activity of Galectins.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Seema R PatelCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Ashley BennettCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Kathryn Girard-PierceCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Cheryl L MaierCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Satheesh ChonatCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Connie M ArthurCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Patricia E ZerraCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Amanda MenerCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Sean R StowellCenter for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA; and.
Emory University · USChildren's Healthcare of Atlanta · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
The Mouse Blood Center CoreP01HL132819 · NHLBI · UNIVERSITY OF VIRGINIA · PI LUCKEY, CHANCE MARION JOHN · 2017 to 2021
$12.2M
Examination of Initiating Factors that Regulate Red Blood Cell AlloimmunizationR01HL135575 · NHLBI · EMORY UNIVERSITY · PI Sean R Stowell · 2017 to 2026
$2.8M
Training Grant in Transfusion Medicine (T32)T32HL069769 · NHLBI · EMORY UNIVERSITY · PI Una T O'Doherty, John D Roback · 2004 to 2026
$2.6M
Examination of Innate Immunity Against Molecular MimicryDP5OD019892 · OD · EMORY UNIVERSITY · PI STOWELL, SEAN R · 2014 to 2018
$2.2M
NHLBI NIH HHS P01 HL132819NHLBI NIH HHS R01 HL135575NHLBI NIH HHS T32 HL069769NIGMS NIH HHS T32 GM008169NIH HHS DP5 OD019892
6 · The paper itself

Abstract

Individuals that become immunized to red blood cell (RBC) alloantigens can experience an increased rate of antibody formation to additional RBC alloantigens following subsequent transfusion. Despite this, how an immune response to one RBC immunogen may impact subsequent alloimmunization to a completely different RBC alloantigen remains unknown. Our studies demonstrate that Kell blood group antigen (KEL) RBC transfusion in the presence of inflammation induced by poly (I:C) (PIC) not only enhances anti-KEL antibody production through a CD4

Indexed as

Immunity, HumoralAnimalsAntibody FormationCD4-Positive T-LymphocytesErythrocytesErythrocyte TransfusionIsoantibodiesIsoantigensMiceIsoantibodiesIsoantigens

Identifiers

PMID29365318
PMCPMC5787868
OpenAlexW2784138475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.