ArticleSchizophrenia bulletin2019
Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Structural and Functional MRI Brain Changes in Patients with Schizophrenia Following Electroconvulsive Therapy: A Systematic Review.Current neuropharmacology · 2022Pooled it
- Meta-analysis of cognitive functioning in patients with psychotic disorders and obsessive-compulsive symptoms.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Resting-state EEG markers associated with violence risk in patients with major depressive disorder.Psychological medicine · 2026Article
- Exploring connectivity and volume alterations in the Pulvinar's subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD).Psychological medicine · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Anhedonia Across and Beyond the Schizophrenia Spectrum.Schizophrenia bulletin · 2025Review
- Functional Connectome Hierarchy in Schizotypy and Its Associations With Expression of Schizophrenia-Related Genes.Schizophrenia bulletin · 2024Article
- Could Cognitive Inflexibility Serve as a Potential Biomarker for Schizophrenia-Obsessive-Compulsive Disorder Spectrum?Biological psychiatry global open science · 2024Article
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Altered intrinsic functional network connectivity is associated with impulsivity and emotion dysregulation in drug-naïve young patients with borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2023Article
- Widespread Intra- and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia.Journal of clinical medicine · 2023Article
- Shared genetic loci and causal relations between schizophrenia and obsessive-compulsive disorder.Schizophrenia (Heidelberg, Germany) · 2023Article
- Diagnostic progression to schizophrenia in 35,255 patients with obsessive-compulsive disorder: a longitudinal follow-up study.European archives of psychiatry and clinical neuroscience · 2023Article
- A comparative study of cognitive functions between schizophrenia and obsessive-compulsive disorder.Heliyon · 2023Article
- Different degrees of nodes behind obsessive-compulsive symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
- The stress-vulnerability model on the path to schizophrenia: Interaction between BDNF methylation and schizotypy on the resting-state brain network.Schizophrenia (Heidelberg, Germany) · 2022Article
- Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity.European archives of psychiatry and clinical neuroscience · 2022Article
- Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.
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