ArticlePloS one2018
Least-detectable and age-related local in vivo bone remodelling assessed by time-lapse HR-pQCT.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease.Frontiers in medicine · 2020Pooled it
- Non-invasive quantification of bone (re)modeling dynamics in adults with osteogenesis imperfecta treated with setrusumab using timelapse high-resolution peripheral-quantitative computed tomography.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- High-impact exercise stimulated localised adaptation of microarchitecture across distal tibia in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Effects of romosozumab on the peripheral and axial skeleton in postmenopausal women at high fracture risk: real-world evidence from DXA and HR-pQCT data.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Virtual bone biopsy: time-lapse high-resolution peripheral quantitative computed tomography provides noninvasive comprehensive skeletal assessment.Current opinion in nephrology and hypertension · 2026Review
- The Use of Time-Lapse High-Resolution Peripheral Quantitative Computed Tomography for Noninvasive Bone Turnover and Bone Quality Assessment in CKD.Journal of the American Society of Nephrology : JASN · 2025Article
- Time-lapse HR-pQCT reliably assesses and monitors local bone turnover in patients with chronic kidney disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Culture system for longitudinal monitoring of bone dynamics ex vivo.Biotechnology and bioengineering · 2025Article
- Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints.Current osteoporosis reports · 2024Review
- Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Mechanostat parameters estimated from time-lapsedFrontiers in bioengineering and biotechnology · 2023Article
- Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation.Scientific reports · 2022Article
- Advancements in Osteoporosis Imaging, Screening, and Study of Disease Etiology.Current osteoporosis reports · 2021Review
- Article
- The utility of multi-stack alignment and 3D longitudinal image registration to assess bone remodeling in rheumatoid arthritis patients from second generation HR-pQCT scans.BMC medical imaging · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously developed an image analysis approach for the determination of local sites of bone remodelling using time-lapse in vivo HR-pQCT. The involved image filtering for removing noise was chosen rather aggressively, and also removed some effects of the bone remodelling. In this paper, we quantify these filtering settings using ex vivo reproducibility HR-pQCT images, and determine the least-detectable bone remodelling using in vivo reproducibility HR-pQCT images, as well as testing whether the approach is capable of capturing age-related bone remodelling by use of in vivo long-term HR-pQCT images. We found that a threshold value of 225 mg HA/cm3 for the filtering led to acceptable results with falsely determined bone remodelling of less than 0.5%, and that the least-detectable bone formation and bone resorption are 2.0 ± 1.0% and 2.2 ± 0.7% respectively. We also found that age-related local bone remodelling can be captured satisfactorily in postmenopausal women. The latter revealed new insights into the effect of ageing on bone remodelling, and showed that bone remodelling seems to take place through a few small formation packets and many large resorption volumes leading to a net bone loss. We conclude that local in vivo bone remodelling can be successfully assessed with time-lapse in vivo HR-pQCT capable of assessing age-related changes in bone remodelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.