ArticleNature2018
The axolotl genome and the evolution of key tissue formation regulators.
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 274 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
274 citing papers in PubMed, 580 citations in OpenAlex.
- Review
- Tenascin C-Derived Peptide 6 Promotes De Novo Kidney Regeneration after Partial Nephrectomy in Axolotl.Journal of the American Society of Nephrology : JASN · 2026Article
- From field to genome: non-lethal, on-site nanopore-only assembly of the endangered Grenada Frog (Pristimantis euphronides).BMC genomics · 2026Article
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- Pancreatic injury induces β-cell regeneration in axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Conserved anterior/posterior tissue asymmetry encodes proximal/distal positional information during axolotl limb regeneration.Cell reports · 2026Article
- Genome-Wide Analysis of an Endangered Axolotl Endemic to Mexico Reveals Genomic Variation Associated with Body Condition, Environment, and Infection by a Pathogenic Fungus.Genome biology and evolution · 2026Article
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
- Single-cell analyses of tissue regeneration in two true jellyfish.Molecular biology and evolution · 2026Article
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- Sea CucumberResearch square · 2026Article
- Insights into cephalochordate genome and gene evolution from the early-diverging amphioxusProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Non-canonical muscle stem cells and other lessons from regenerative vertebrates.NPJ Regenerative medicine · 2026Review
- Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.The EMBO journal · 2026Article
- A spatial transcriptomics comparison of the adult versus metamorphosed axolotl brain.Scientific data · 2026Article
- Divergence at the IRX gene cluster underlies extreme trophic polymorphism in a cichlid fish (Herichthys minckleyi).Communications biology · 2026Article
- Two axolotl-adapted cell-ablation platforms reveal macrophage-dependent processes essential for spinal-cord and skeletal regeneration.bioRxiv : the preprint server for biology · 2026Article
- Divergent stem cell mechanisms govern the primary body axis and appendage regeneration in the axolotl.Science advances · 2026Article
214 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
19 authors at 10 institutions in 7 countries.
Funding
Abstract
Salamanders serve as important tetrapod models for developmental, regeneration and evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma mexicanum) a key representative salamander for molecular investigations. Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined long-read sequencing, optical mapping and development of a new genome assembler (MARVEL). We observed a size expansion of introns and intergenic regions, largely attributable to multiplication of long terminal repeat retroelements. We provide evidence that intron size in developmental genes is under constraint and that species-restricted genes may contribute to limb regeneration. The axolotl genome assembly does not contain the essential developmental gene Pax3. However, mutation of the axolotl Pax3 paralogue Pax7 resulted in an axolotl phenotype that was similar to those seen in Pax3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.