Evidence map›Paper›PMID 29364757›Full record

ReviewJournal of dental research2018

A Force on the Crown and Tug of War in the Periodontal Complex.

A T Jang, L Chen, A R Shimotake, W Landis, V Altoe, S Aloni, M Ryder, S P Ho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Functional adaptation of interradicular alveolar bone to reduced chewing loads on dentoalveolar joints in rats.Dental materials : official publication of the Academy of Dental Materials · 2021
    Article
  7. Frontiers in cellular and infection microbiology · 2021
    Article
  8. Biglycan in the Skeleton.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A T Jang1 Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
L Chen1 Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
A R Shimotake1 Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
W Landis1 Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
V Altoe2 Materials Science Division, The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
S Aloni2 Materials Science Division, The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
M Ryder3 Division of Periodontics, Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
S P Ho1 Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.

Funding

Load-mediated Adaptation of the Bone-PDL-Tooth Complex in VertebratesR01DE022032 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2012 to 2021
$3.4M
High Resolution Non-Invasive Imaging of Oral and Craniofacial TissuesS10RR026645 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026645NIDCR NIH HHS R01 DE022032
6 · The paper itself

Abstract

The load-bearing dentoalveolar fibrous joint is composed of biomechanically active periodontal ligament (PDL), bone, cementum, and the synergistic entheses of PDL-bone and PDL-cementum. Physiologic and pathologic loads on the dentoalveolar fibrous joint prompt natural shifts in strain gradients within mineralized and fibrous tissues and trigger a cascade of biochemical events within the widened and narrowed sites of the periodontal complex. This review highlights data from in situ biomechanical simulations that provide tooth movements relative to the alveolar socket. The methods and subsequent results provide a reasonable approximation of strain-regulated biochemical events resulting in mesial mineral formation and distal resorption events within microanatomical regions at the ligament-tethered/enthesial ends. These biochemical events, including expressions of biglycan, decorin, chondroitin sulfated neuroglial 2, osteopontin, and bone sialoprotein and localization of various hypertrophic progenitors, are observed at the alkaline phosphatase-positive widened site, resulting in mineral formation and osteoid/cementoid layers. On the narrowed side, tartrate-resistant acid phosphatase regions can lead to a sequence of clastic activities resulting in resorption pits in bone and cementum. These strain-regulated biochemical and subsequently biomineralization events in the load-bearing periodontal complex are critical for maintenance of the periodontal space and overall macroscale joint biomechanics.

Indexed as

Adaptation, PhysiologicalAnimalsBiomechanical PhenomenaBone and BonesDental CementumDental Stress AnalysisHumansMasticationMouth DiseasesPeriodontal LigamentTooth Crowndentoalveolarenthesesinterfacemechanobiologyperiodontal ligamentX-ray computed tomography

Identifiers

PMID29364757
PMCPMC5833186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.